Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects

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Adeli Mehr A.; Baheiraei N.; Eyni h.

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Journal: Pathobiology Research Year:2019 | Volume:22 | Issue:3 Page(s): 141-147

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Information Journal Paper

Title

Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects

Author(s)

Adeli Mehr A. | Baheiraei N. | Eyni h. | Issue Writer Certificate

Keywords

Tissue EngineeringQ2

BioactiveQ1

StrontiumQ1

OsteogenesisQ1

Abstract

Aims Growing experiments show that biomaterials that have a Bioactive glass (BG) indicate encouraging effects on bone tissue repair. Strontium-substituted BGs (BG/Sr) have been confirmed to improve bone formation while preventing bone resorption by osteoclasts. Materials and Methods This study aimed to evaluate the potential of Strontium substitution on bioglass/gelatin (Gel) Osteogenesis in critically sized rabbit calvarial defects. Defects were treated with Gel-BG or Gel-BG/Sr scaffolds and one defect was left unfilled as a control. Bone regeneration and mineralization process were evaluated by hematoxylin and eosin, Masson’ s trichrome and Alizarin Red staining after 4 and 8 weeks post-implantation. Findings Based on the histological findings, newly formed bone area in scaffolds containing BG/Sr was greater than that without Sr after 8 weeks. Conclusion Our results specified that BG/Sr containing scaffolds could better increase bone regeneration than those without Sr and could be considered as a bone graft in bone Tissue Engineering.

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APA: Copy

Adeli Mehr, A., Baheiraei, N., & Eyni, h.. (2019). Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 22(3 ), 141-147. SID. https://sid.ir/paper/402230/en

Vancouver: Copy

Adeli Mehr A., Baheiraei N., Eyni h.. Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2019;22(3 ):141-147. Available from: https://sid.ir/paper/402230/en

IEEE: Copy

A. Adeli Mehr, N. Baheiraei, and h. Eyni, “Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 22, no. 3 , pp. 141–147, 2019, [Online]. Available: https://sid.ir/paper/402230/en

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