IMMUNOMODULATION WITH EPIGALLOCATECHIN GALLATE IN INJURED SPINAL CORD OF RATS

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KHALATBARY A.R.; AHMADVAND H.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:20 | Issue:79 Page(s): 1-7

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Title

IMMUNOMODULATION WITH EPIGALLOCATECHIN GALLATE IN INJURED SPINAL CORD OF RATS

Author(s)

KHALATBARY A.R. | AHMADVAND H. | Issue Writer Certificate

Keywords

EPIGALLOCATECHIN GALLATEQ2

IMMUNOHISTOCHEMISTRYQ2

RATSQ2

SPINAL CORD INJURIESQ2

Abstract

Introduction: Spinal cord injury (SCI) stimulates an immune response that causes substantial secondary damage inside the injured spinal tissue.Objective: To determine the immunomodulatory effects of EPIGALLOCATECHIN GALLATE (EGCG) on traumatized spinal cord of RATS.Materials and Methods: RATS were randomly divided into three groups of 7 RATS each as follows: negative control group, positive control group, and experimental group (50mg/kg EGCG, i.p., immediately after SCI). Spinal cord samples were collected 24 hours after injury and studied for IMMUNOHISTOCHEMISTRY of CD4, TNF-a, IL-1b, iNOS and COX-2.Results: EPIGALLOCATECHIN GALLATE attenuated immunohistochemical expression of immune-related response criteria.Conclusion: On the basis of these findings, we propose that EGCG may be effective in protecting the rat spinal cord from secondary damage by modulating of immune responses.

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APA: Copy

KHALATBARY, A.R., & AHMADVAND, H.. (2011). IMMUNOMODULATION WITH EPIGALLOCATECHIN GALLATE IN INJURED SPINAL CORD OF RATS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 20(79), 1-7. SID. https://sid.ir/paper/40261/en

Vancouver: Copy

KHALATBARY A.R., AHMADVAND H.. IMMUNOMODULATION WITH EPIGALLOCATECHIN GALLATE IN INJURED SPINAL CORD OF RATS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;20(79):1-7. Available from: https://sid.ir/paper/40261/en

IEEE: Copy

A.R. KHALATBARY, and H. AHMADVAND, “IMMUNOMODULATION WITH EPIGALLOCATECHIN GALLATE IN INJURED SPINAL CORD OF RATS,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 79, pp. 1–7, 2011, [Online]. Available: https://sid.ir/paper/40261/en

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