Comparison of the prevalence of HBV, HCV, HIV, CMV and EBV infections in patients with systemic lupus erythromatosus and healthy population

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Hashempour Ava; MOAYEDI JAVAD; Musavi Zahra; Nazarinia Mohammad Ali; Hasanshahi Zahra; Ghasabi Farzaneh; Halaji Mehrdad

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Journal: Tehran University Medical Journal Year:2021 | Volume:79 | Issue:2 Page(s): 93-101

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Title

Comparison of the prevalence of HBV, HCV, HIV, CMV and EBV infections in patients with systemic lupus erythromatosus and healthy population

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Keywords

cytomegalovirusQ1

epstein-barr virusQ1

hepatitisQ3

lupusQ2

viral infectionsQ2

Abstract

Background: Systemic lupus erythematosus is a systemic autoimmune disease that affects almost all organs of the body, and viral infections are involved in its development and progression. The present study aimed to evaluate the serological status of some viral infections in patients with systemic lupus erythematosus and a healthy population. Methods: This descriptive study conducted from May 2017 to April 2018 at Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran on 70 patients with systemic lupus erythematosus and 70 healthy individuals who had no autoimmune diseases and were matched with the patient group for age and sex. All patients had active records and were routinely visited in rheumatology clinic of Hafez hospital, affiliated with Shiraz University of Medical Sciences. The evidence of active disease was assessed by the physicians of this practice according to the American College of Rheumatology criteria. Peripheral blood samples were collected in tubes containing EDTA and centrifuged at 3000 rpm for 5 min. The plasma of study participants was evaluated for HBsAg, HCVAb, HIVAb, EBV-VCA-IgG, and CMVIgG using a commercially available ELISA kit. Results: The seropositivity of CMV-IgG and EBV-VCA-IgG in the systemic lupus erythematosus group was 70 (100%) and 65 (92. 9%), and in healthy individuals was 68 (97. 1%) and 57 (81. 4%), respectively. The prevalence of EBV-VCA-IgG in the systemic lupus erythematosus group was significantly higher than healthy ones (P=0. 043). The optical density (OD) of CMV-IgG and EBV-VCA-IgG in patients with systemic lupus erythematosus was significantly higher than in healthy individuals (P<0. 0001). All patients with systemic lupus erythematosus were negative for HBsAg and HIVAb, but HCVAb was detected in 1 (1. 4%) patient. Conclusion: Considering the higher frequency of EBV-VCA-IgG and the higher titer of antibodies against CMV and EBV in patient groups compared to healthy individuals group, it seems that periodical assessment of viral load in patients with systemic lupus erythematosus will be beneficial to prescribe medication by physicians if it is needed.

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APA: Copy

Hashempour, Ava, MOAYEDI, JAVAD, Musavi, Zahra, Nazarinia, Mohammad Ali, Hasanshahi, Zahra, Ghasabi, Farzaneh, & Halaji, Mehrdad. (2021). Comparison of the prevalence of HBV, HCV, HIV, CMV and EBV infections in patients with systemic lupus erythromatosus and healthy population. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 79(2 ), 93-101. SID. https://sid.ir/paper/403116/en

Vancouver: Copy

Hashempour Ava, MOAYEDI JAVAD, Musavi Zahra, Nazarinia Mohammad Ali, Hasanshahi Zahra, Ghasabi Farzaneh, Halaji Mehrdad. Comparison of the prevalence of HBV, HCV, HIV, CMV and EBV infections in patients with systemic lupus erythromatosus and healthy population. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2021;79(2 ):93-101. Available from: https://sid.ir/paper/403116/en

IEEE: Copy

Ava Hashempour, JAVAD MOAYEDI, Zahra Musavi, Mohammad Ali Nazarinia, Zahra Hasanshahi, Farzaneh Ghasabi, and Mehrdad Halaji, “Comparison of the prevalence of HBV, HCV, HIV, CMV and EBV infections in patients with systemic lupus erythromatosus and healthy population,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 79, no. 2 , pp. 93–101, 2021, [Online]. Available: https://sid.ir/paper/403116/en

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