RELATIONSHIP OF HER-2 WITH OTHER CLINICAL - PATHOLOGICAL DIAGNOSTIC CRITERIA IN BREAST CANCER PATIENTS

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NAJAFI B.A.D.; FAKHERI T.; FADAKARE SOGHEH GH.

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Journal: Journal of Guilan University of Medical Sciences Year:2006 | Volume:15 | Issue:57 Page(s): 21-27

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Title

RELATIONSHIP OF HER-2 WITH OTHER CLINICAL - PATHOLOGICAL DIAGNOSTIC CRITERIA IN BREAST CANCER PATIENTS

Author(s)

NAJAFI B.A.D. | FAKHERI T. | FADAKARE SOGHEH GH. | Issue Writer Certificate

Keywords

BREAST NEOPLASMQ3

MEMBRANE PROTEINSQ2

RECEPTORSQ3

STEROIDQ3

Abstract

Introduction: HER-2/neu is a membrane protein and it is one of the determining prognostic factors of breast cancerObjective: The aim of the study was to investigate the relationship between the expression of the HER-2 membrane protein and clinical- pathological parameters such as size: degree of the tumor differentiation, presence or absence of lymphovascular invasion and its relation with STEROID hormone and P53 status in breast cancer patientsMaterials and Methods: This descriptive study was done on 465 cases of breast cancers referred to two cancer centers in Gilan from 1980-1985. Patients’ demographic data, pathological and type of clinical therapy were gathered from their medical charts. All membrane samples taken by biopsy were embedded in paraffin and stained by hematoxylin-eosin technique and were evaluation by a semi-quantitative method of immunohisto- chemistery for HER2 protein, P53 and STEROIDal receptor.Results: A total of 32% of breast cancer patients had positive HER2 protein. There was a positive correlation between HER2 protein and P53 protein expression (P=0.000). There was a positive relationship between presence of HER2 protein and absence of STEROID receptor with high-grade tumor (grade 3)(P=0.3) and absence of HER2 and presence of STEROID receptor with low-grade tumor (grade 1) (P=0.5). There was no correlation between HER2 and lymphovascular invasion and size of tumor.Conclusion: In breast cancer patients, there is a positive correlation between presence of HER2 protein and degree of tumor differentiation and it also correlates with poor prognostic factors such as hormone receptor negativity and P53 positivity.

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APA: Copy

NAJAFI, B.A.D., FAKHERI, T., & FADAKARE SOGHEH, GH.. (2006). RELATIONSHIP OF HER-2 WITH OTHER CLINICAL - PATHOLOGICAL DIAGNOSTIC CRITERIA IN BREAST CANCER PATIENTS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 15(57), 21-27. SID. https://sid.ir/paper/40339/en

Vancouver: Copy

NAJAFI B.A.D., FAKHERI T., FADAKARE SOGHEH GH.. RELATIONSHIP OF HER-2 WITH OTHER CLINICAL - PATHOLOGICAL DIAGNOSTIC CRITERIA IN BREAST CANCER PATIENTS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;15(57):21-27. Available from: https://sid.ir/paper/40339/en

IEEE: Copy

B.A.D. NAJAFI, T. FAKHERI, and GH. FADAKARE SOGHEH, “RELATIONSHIP OF HER-2 WITH OTHER CLINICAL - PATHOLOGICAL DIAGNOSTIC CRITERIA IN BREAST CANCER PATIENTS,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 57, pp. 21–27, 2006, [Online]. Available: https://sid.ir/paper/40339/en

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