Effect of co-trimaxazole on REP-529 and TNF-α transcription levels in the brain of Toxoplasma gondii infected-mice

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BABAIE JALAL; SAYYAH MOHAMMAD; GOLKAR MAJID

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Journal: IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Year:2019 | Volume:3 | Issue:2 (10) Page(s): 99-107

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Information Journal Paper

Title

Effect of co-trimaxazole on REP-529 and TNF-α transcription levels in the brain of Toxoplasma gondii infected-mice

Author(s)

BABAIE JALAL | SAYYAH MOHAMMAD | GOLKAR MAJID | Issue Writer Certificate

Keywords

Toxoplasma gondii

Co-trimoxazole

TNF-α

REP-529

Abstract

Background and aims: Toxoplasmosis is a globally prevalent parasitic infection caused by Toxoplasma gondii. A flu-like syndrome is seen in the acute phase of infection with no obvious symptoms in the chronic phase. In this study effect of co-trimaxazole on parasite load and inflammation in the brain of infected mice was examined. Methods: Mice were infected by intraperitoneal injection T. gondii cysts. Transcription of REP-529 (as indicator of parasite load) and TNF-α; (as indicator of inflammation) were measured in the mice brain by RT-qPCR, at weeks 1-8 after injection of cysts, and after treatment with Co-trimoxazole. Co-trimoxazole was administered 10 days before the weeks 4 and 8 of the infection for 10 days. Results: Severe ascites was observed during 4-14 days after injection of cysts. The REP-529 transcription level indicates that the parasite enters the brain 1 week after cyst injection and proliferated rapidly in the second and third weeks. TNF-α; level increased and reached the maximum level in the second week and then decreased in the next weeks. Co-trimoxazole significantly reduced transcription of both REP-529 and TNF-α; during 4 and 8 weeks of infection. Co-trimoxazole caused significant (p < 0. 01) weight gain in mice at the week 4 of infection compared to the untreated group. Conclusion We found chronic administration of Co-trimoxazole to mice infected by T. gondii can inhibit parasite proliferation and inflammation in the brain and cure the disease.

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APA: Copy

BABAIE, JALAL, SAYYAH, MOHAMMAD, & GOLKAR, MAJID. (2019). Effect of co-trimaxazole on REP-529 and TNF-α transcription levels in the brain of Toxoplasma gondii infected-mice. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 3(2 (10) ), 99-107. SID. https://sid.ir/paper/403844/en

Vancouver: Copy

BABAIE JALAL, SAYYAH MOHAMMAD, GOLKAR MAJID. Effect of co-trimaxazole on REP-529 and TNF-α transcription levels in the brain of Toxoplasma gondii infected-mice. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;3(2 (10) ):99-107. Available from: https://sid.ir/paper/403844/en

IEEE: Copy

JALAL BABAIE, MOHAMMAD SAYYAH, and MAJID GOLKAR, “Effect of co-trimaxazole on REP-529 and TNF-α transcription levels in the brain of Toxoplasma gondii infected-mice,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 3, no. 2 (10) , pp. 99–107, 2019, [Online]. Available: https://sid.ir/paper/403844/en

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