Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model

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Momtaz Saeideh; ABDOLGHAFFARI AMIR HOSSEIN; Jasemi Eghbal; Yaqoobvand Bahman; Esmaeilzadeh Saeed; ABDOLLAHI ALIREZA; ABDOLLAHI MOHAMMAD

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Journal: Journal of Medicinal Plants Year:2021 | Volume:20 | Issue:77 Page(s): 37-49

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Title

Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model

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Keywords

Althaea officinalisQ1

Lavandula angustifoliaQ2

Rosa x damascenaQ2

Excision wound healingQ1

InflammationQ2

Abstract

Background: Althaea officinalis L., Lavandula angustifolia Mill. and Rosa x damascena Herrm. are used to treat excision or burn lesions in traditional medicine. Objective: To evaluate the healing effect of a polyherbal ointment containing L. angustifolia, R. x damascena, and A. officinalis combination on wounds caused by third grade skin cut. Methods: To evaluate the wound healing effect of this polyherbal formulation, an ointment containing the extract of A. officinalis, the essential oil of R. x damascena (2 % essence) and the essential oil of L. officinalis (2 % essence) in an eucerin base (20: 20: 10: 50) was prepared. The formulation was examined using excision wound test for 14 days and the percentage of healing effect in each group was calculated. Formalin induced rat hind paw edema method was used for determination of anti-inflammatory activities of the same formulation. Results: The percentage of recovery in the polyherbal formulation group was significantly higher than the other groups. Histological studies also confirmed these results. Herbal formulation treated group showed significant improvement in terms of re-epithelialization, angiogenesis, collagen deposition, and reducing Inflammation. The percentage of wound healing was 99. 07 ± 0. 34, 99. 22 ± 0. 35, 98. 45 ± 0. 733, 98. 75 ± 0. 88 and 63. 72 ± 5. 64, for the polyherbal formulation, L. angustifolia, R. damascena, A. officinalis extracts, and the placebo group, respectively. Conclusion: This polyherbal formulation could act as a wound healing agent, possibly due to the suppression of inflammatory mediators. The presence of phenolic compounds might be a reason behind the therapeutic effect of these plants.

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APA: Copy

Momtaz, Saeideh, ABDOLGHAFFARI, AMIR HOSSEIN, Jasemi, Eghbal, Yaqoobvand, Bahman, Esmaeilzadeh, Saeed, ABDOLLAHI, ALIREZA, & ABDOLLAHI, MOHAMMAD. (2021). Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model. JOURNAL OF MEDICINAL PLANTS, 20(77 ), 37-49. SID. https://sid.ir/paper/404112/en

Vancouver: Copy

Momtaz Saeideh, ABDOLGHAFFARI AMIR HOSSEIN, Jasemi Eghbal, Yaqoobvand Bahman, Esmaeilzadeh Saeed, ABDOLLAHI ALIREZA, ABDOLLAHI MOHAMMAD. Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model. JOURNAL OF MEDICINAL PLANTS[Internet]. 2021;20(77 ):37-49. Available from: https://sid.ir/paper/404112/en

IEEE: Copy

Saeideh Momtaz, AMIR HOSSEIN ABDOLGHAFFARI, Eghbal Jasemi, Bahman Yaqoobvand, Saeed Esmaeilzadeh, ALIREZA ABDOLLAHI, and MOHAMMAD ABDOLLAHI, “Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model,” JOURNAL OF MEDICINAL PLANTS, vol. 20, no. 77 , pp. 37–49, 2021, [Online]. Available: https://sid.ir/paper/404112/en

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