EFFECT OF THE ADENOSINE A1 RECEPTOR AGONIST ON DEMYELINATION AND REMYELINATION PROCESSES IN LYSOLECITHIN INDUCED DEMYELINATION IN RAT OPTIC CHIASM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASGHARI A.; AZARNIA M.; MIRNAJAFIZADEH S.J.; JAVAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2012 | Volume:16 | Issue:1 (SERIAL 61) Page(s): 1-8

Download Full-Text

Persian Verion

View:

710

Download:

Cites:

Information Journal Paper

Title

EFFECT OF THE ADENOSINE A1 RECEPTOR AGONIST ON DEMYELINATION AND REMYELINATION PROCESSES IN LYSOLECITHIN INDUCED DEMYELINATION IN RAT OPTIC CHIASM

Author(s)

ASGHARI A. | AZARNIA M. | MIRNAJAFIZADEH S.J. | JAVAN M. | Issue Writer Certificate

Keywords

DEMYELINATIONQ2

REMYELINATIONQ3

MULTIPLE SCLEROSISQ1

N6-CYCLOHEXYLADENOSINEQ2

VISUAL EVOKED POTENTIALQ2

OLIGODENDROCYTE PROGENITOR CELLSQ2

NEURAL STEM CELLSQ2

RATQ2

Abstract

Background: DEMYELINATION in central nervous system is usually followed by REMYELINATION; however, chronic lesions with subsequent functional impairment result from the eventual failure of REMYELINATION process, as seen in MULTIPLE SCLEROSIS. REMYELINATION is the process through which oligodendrocyte-progenitor cells (OPCs) restore new myelin sheathes around demyelinated axons. This study aimed to investigate the effect of A1 receptor agonist, N6-CYCLOHEXYLADENOSINE (CHA), on the DEMYELINATION and REMYELINATION processes in RAT optic chiasm following lysophosphatidylcholine (LPC) -induced demylination.Materials and Methods: In this experimental study, LPC was injected into the optic chiasm of three groups of RATs (n=6). Control group received aCSF on different days following LPC injection. Two groups of animals received CHA on days 0- 14 or 14 - 28 post - lesion.DEMYELINATION and REMYELINATION levels were evaluated by recording VISUAL EVOKED POTENTIAL (VEP) from the scalp.Results: The highest level of DEMYELINATION was occurred on day 7 post - lesion LPC injection and gradually reduced during the days 7- 28. The P-wave latency was significantly increased on day 7 and then partially restored during the days 7- 28 post-lesion. CHA administration during the days 0- 14 attenuated DEMYELINATION process. In addition, CHA administration in REMYELINATION phase (days 14-28) was able to potentiate the endogenous myelin repair.Conclusion: Injection of CHA could prevent the lysolecithin-induced variations in VEP.The effects of CHA may be mediated through increment of OPCs proliferation and their differentiation into myelinating oligodendrocytes.

Cites

No record.

References

No record.

Cite

APA: Copy

ASGHARI, A., AZARNIA, M., MIRNAJAFIZADEH, S.J., & JAVAN, M.. (2012). EFFECT OF THE ADENOSINE A1 RECEPTOR AGONIST ON DEMYELINATION AND REMYELINATION PROCESSES IN LYSOLECITHIN INDUCED DEMYELINATION IN RAT OPTIC CHIASM. FEYZ, 16(1 (SERIAL 61)), 1-8. SID. https://sid.ir/paper/404356/en

Vancouver: Copy

ASGHARI A., AZARNIA M., MIRNAJAFIZADEH S.J., JAVAN M.. EFFECT OF THE ADENOSINE A1 RECEPTOR AGONIST ON DEMYELINATION AND REMYELINATION PROCESSES IN LYSOLECITHIN INDUCED DEMYELINATION IN RAT OPTIC CHIASM. FEYZ[Internet]. 2012;16(1 (SERIAL 61)):1-8. Available from: https://sid.ir/paper/404356/en

IEEE: Copy

A. ASGHARI, M. AZARNIA, S.J. MIRNAJAFIZADEH, and M. JAVAN, “EFFECT OF THE ADENOSINE A1 RECEPTOR AGONIST ON DEMYELINATION AND REMYELINATION PROCESSES IN LYSOLECITHIN INDUCED DEMYELINATION IN RAT OPTIC CHIASM,” FEYZ, vol. 16, no. 1 (SERIAL 61), pp. 1–8, 2012, [Online]. Available: https://sid.ir/paper/404356/en

Related Journal Papers