The effect of hydro-alchoholic exteract of (Matricaria recutita L. ) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice

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kazemi kazemi; Ghavipanjeh Gh.; SHAHABODDIN M.E.; Banitaba Bidgoli M.

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Journal: Feyz Medical Sciences Journal Year:2018 | Volume:22 | Issue:4 Page(s): 346-354

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Title

The effect of hydro-alchoholic exteract of (Matricaria recutita L. ) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice

Author(s)

kazemi kazemi | Ghavipanjeh Gh. | SHAHABODDIN M.E. | Banitaba Bidgoli M. | Issue Writer Certificate

Keywords

EpilepsyQ2

SeizureQ3

Matricaria recutita L.Q2

Nitric oxideQ2

MiceQ2

Abstract

Background: Matricaria recutit (MAT) has a series of flavonoid compounds with benzodiazepine-like properties. So, it may be effective in the treatment of Epilepsy and Seizures. This study aimed at examining the effect of intraperitoneal injection of the hydroalcoholic extract of Matricaria recutita on Seizures induced by pentylenetetrazole (PTZ) in Mice. Materials and Methods: In this study, 56 male Mice (25-30 g) were divided into seven groups (n=8): 1-control (saline), 2-control (PTZ), 3-MAT (50mg/kg), 4-MAT (100 mg/kg), 5-MAT (200 mg/kg), 6-diazepam (1mg/kg) and 7-MAT (50 mg/kg)+diazepam (0. 25 mg/kg). After 10 days of treatment in different groups, the PTZ-induced Seizure threshold was assessed and Nitric oxide (NOX) metabolites in the brain tissue were measured by the Greiss method. Results: The chamomile hydro-alcoholic extract (200 mg/kg), and diazepam (1 mg/kg) significantly increased the Seizure threshold (P<0. 001). The chamomile hydro-alcoholic extract (50, and 100 mg/kg) did not show anticonvulsant activity. The concentrations of NOX in the diazepam (1 mg/kg), MAT 100 mg/kg, and MAT 200 mg/kg groups were significantly lower than those in the control (PTZ) group and co-administration of MAT (50 mg/kg) with diazepam (0. 25) decreased the NOX concentration. The hydro-alcoholic extract of MAT (50 mg/kg) had no significant effect on the NOX concentration. Conclusion: According to the results of this study, the chamomile hydro-alcoholic extract has an inhibitory effect on the PTZ-induced Seizure and NOX in male Mice.

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References

A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)

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APA: Copy

kazemi, kazemi, Ghavipanjeh, Gh., SHAHABODDIN, M.E., & Banitaba Bidgoli, M.. (2018). The effect of hydro-alchoholic exteract of (Matricaria recutita L. ) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice. FEYZ, 22(4 ), 346-354. SID. https://sid.ir/paper/40493/en

Vancouver: Copy

kazemi kazemi, Ghavipanjeh Gh., SHAHABODDIN M.E., Banitaba Bidgoli M.. The effect of hydro-alchoholic exteract of (Matricaria recutita L. ) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice. FEYZ[Internet]. 2018;22(4 ):346-354. Available from: https://sid.ir/paper/40493/en

IEEE: Copy

kazemi kazemi, Gh. Ghavipanjeh, M.E. SHAHABODDIN, and M. Banitaba Bidgoli, “The effect of hydro-alchoholic exteract of (Matricaria recutita L. ) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice,” FEYZ, vol. 22, no. 4 , pp. 346–354, 2018, [Online]. Available: https://sid.ir/paper/40493/en

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