Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population

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REZAIE F.; NEZHADALI M.; HEDAYATI M.

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Journal: Feyz Medical Sciences Journal Year:2018 | Volume:22 | Issue:4 Page(s): 379-386

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Information Journal Paper

Title

Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population

Author(s)

REZAIE F. | NEZHADALI M. | HEDAYATI M. | Issue Writer Certificate

Keywords

Non-alcoholic fatty liverQ1

AdiponectinQ2

PolymorphismQ2

Adipose tissueQ2

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, resulting from exceeding fat cumulating in the liver. Adiponectin, a protein secreted from the Adipose tissue, reduces liver inflammation. In this study, the relationship between Adiponectin rs17300539 gene Polymorphism and a Non-alcoholic fatty liver disease was investigated. Materials and Methods: This case-control study was conducted on 80 subjects with NAFLD and 80 healthy subjects. The determination of Polymorphism rs17300539 of Adiponectin gene was performed by the PCR-RFLP method and electrophoresis technique. The plasma levels of Adiponectin and insulin hormones were measured by an enzyme-linked immunosorbent assay (ELISA) kit. Results: The results showed that there was no significant difference in allele frequencies between the two groups of the case and control (P>0. 05). The body mass index (BMI) in genotype GA carriers was higher than that of genotype GG carriers (P<0. 05). Moreover, the diastolic blood pressure in the male patients carrying the genotype GA was higher than that in the genotype GG carriers (P<0. 05). In the female patients carrying the genotype GA, the AST and triglyceride levels were higher than the GG female carriers (P<0. 05). Conclusion: It seems that the allele G can be beneficial in reducing the side-effects of the Non-alcoholic fatty liver disease.

Cites

Association of adiponectin gene rs2241766 polymorphism with serum adiponectin level, Insulin resistance and type 2 diabetes mellitus in an Iranian population

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APA: Copy

REZAIE, F., NEZHADALI, M., & HEDAYATI, M.. (2018). Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population. FEYZ, 22(4 ), 379-386. SID. https://sid.ir/paper/40499/en

Vancouver: Copy

REZAIE F., NEZHADALI M., HEDAYATI M.. Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population. FEYZ[Internet]. 2018;22(4 ):379-386. Available from: https://sid.ir/paper/40499/en

IEEE: Copy

F. REZAIE, M. NEZHADALI, and M. HEDAYATI, “Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population,” FEYZ, vol. 22, no. 4 , pp. 379–386, 2018, [Online]. Available: https://sid.ir/paper/40499/en

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