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Title

Design and synthesizing appropriate carrier for release of dexamethasone as an anticancer drug

Pages

  389-395

Abstract

 Introduction: One of the effective drugs in the treatment of cancer is Dexamethasone. Dexamethasone is known as one of the safest glucocorticoid, but there is still side-effects, due to its hydrophobicity and low bioavailability. The purpose of the present study is to design a controlled release carrier for Dexamethasone in order to overcome constraints and reduce side effects. Materials and Methods: In the current experimental study, electrospun fibers were prepared in three Polylactic Acid concentrations of 10% (w/v), 14% (w/v) and 18% (w/v) containing 5% (w/v) Dexamethasone and were broken by aminolysis process using 1. 6 diaminohexan / isopropanol. The morphology of the fibers and broken fibers was evaluated by scanning electron microscopy. The amount of drug loaded and cumulative percentage of drug-released from the broken fibers was determined in 144 h. Results: The result of fiber morphology evaluation showed that fiber diameter of 18% (w/v) compared to 14% (w/v) and in 14% (w/v) compared to 10% (w/v) increased by 13. 1% and 17. 5% respectively. Length of broken fibers in sample 18% (w/v) compared to 14% (w/v) and in the sample 14% (w/v) compared to 10% (w/v) decreased by 24. 07% and 7. 8%, respectively. The drug loading efficacy in broken fibers was 85%. The cumulative release of Dexamethasone from the broken fibers increased with increasing polymer concentration. Conclusion: The design of a Polylactic Acid non-spherical controlled-release release system with a zero-degree release model can be useful for increasing therapeutic efficacy and reducing the side effects of high-dose Dexamethasone.

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    APA: Copy

    Mirazizi, Zahra, KHORSHIDI, SAJEDEH, & KARKHANEH, AKBAR. (2020). Design and synthesizing appropriate carrier for release of dexamethasone as an anticancer drug. KOOMESH, 22(3 (79) ), 389-395. SID. https://sid.ir/paper/405551/en

    Vancouver: Copy

    Mirazizi Zahra, KHORSHIDI SAJEDEH, KARKHANEH AKBAR. Design and synthesizing appropriate carrier for release of dexamethasone as an anticancer drug. KOOMESH[Internet]. 2020;22(3 (79) ):389-395. Available from: https://sid.ir/paper/405551/en

    IEEE: Copy

    Zahra Mirazizi, SAJEDEH KHORSHIDI, and AKBAR KARKHANEH, “Design and synthesizing appropriate carrier for release of dexamethasone as an anticancer drug,” KOOMESH, vol. 22, no. 3 (79) , pp. 389–395, 2020, [Online]. Available: https://sid.ir/paper/405551/en

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