Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran

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jazini Mahboobeh; ROGHANIAN RASOUL; ZARKESH ESFAHANI SEYED HAMID; SHAYGANNEJAD VAHID; Mirmosayyeb Omid

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:1 Page(s): 50-58

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Title

Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran

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Keywords

Neuromyelitis opticaQ1

Mumps virusQ1

ELISAQ2

MSQ2

IgGQ2

Abstract

Background: Neuromyelitis optica (NMO) is an autoimmune inflammation of central nervous system in which autoantibodies are released against AQP-4 (astrocytic water channels) and diagnosed with transverse myelitis and optic neuritis. Viral infections could be pro-inflammatory agents in body organs including nervous system. Due to such inflammatory reactions, autoantibodies would cross the blood brain barrier. Therefore, recognizing the viral agents may help us to prevent and treat NMO. The aim of the present study was to assess the possible association between NMO and Mumps virus. Methods: This observational study was conducted on 25 NMO patients, 30 Multiple Sclerosis (MS) patients and 30 healthy individuals. Serum IgG and IgM antibodies against mumps, was detected by ELISA using Euroimmun kit (manufactured by Germany). Statistical analysis was performed by SPSS software. Results: IgG titer was positive in 76, 53 and 46% of NMO patients, MS patients and healthy individuals, respectively. Statistical analysis demonstrated that level of IgG was significantly higher among groups, However, IgM levels showed no significant difference. Conclusion: Significant increase of IgG titer against Mumps virus in NMO patients and low level of IgM may indicate that an old infection of mumps in NMO patients’ life could have a possible role in the pathogenesis of NMO.

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APA: Copy

jazini, Mahboobeh, ROGHANIAN, RASOUL, ZARKESH ESFAHANI, SEYED HAMID, SHAYGANNEJAD, VAHID, & Mirmosayyeb, Omid. (2019). Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(1 ), 50-58. SID. https://sid.ir/paper/406048/en

Vancouver: Copy

jazini Mahboobeh, ROGHANIAN RASOUL, ZARKESH ESFAHANI SEYED HAMID, SHAYGANNEJAD VAHID, Mirmosayyeb Omid. Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(1 ):50-58. Available from: https://sid.ir/paper/406048/en

IEEE: Copy

Mahboobeh jazini, RASOUL ROGHANIAN, SEYED HAMID ZARKESH ESFAHANI, VAHID SHAYGANNEJAD, and Omid Mirmosayyeb, “Evaluation of the possible relation between neuromyelitis optica and mumps infection in Isfahan, Iran,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 1 , pp. 50–58, 2019, [Online]. Available: https://sid.ir/paper/406048/en

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