Immunology of Behcet disease: review article

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SALMANINEJAD ARASH; SHARIATIZI SAJJAD; ZAMANI MOHAMMAD REZA; SHAKOORI ABBAS

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2019 | Volume:77 | Issue:10 Page(s): 605-614

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Title

Immunology of Behcet disease: review article

Author(s)

SALMANINEJAD ARASH | SHARIATIZI SAJJAD | ZAMANI MOHAMMAD REZA | SHAKOORI ABBAS | Issue Writer Certificate

Keywords

autoimmune diseasesQ1

Behcet syndromeQ2

immunologyQ2

Abstract

Behç et's disease (BD), also known as the Silk Road disease, is a multisystemic and rare inflammatory disorder primarily prevalent in populations along the Mediterranean Sea. Today, BD is defined as a crossroad between autoimmune and auto-inflammatory syndromes. Variety of syndromes including mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosum as well as ocular, vascular, gastrointestinal and nervous system occur. The disease etiology has not yet been elaborated, though researchers have reported several reasons that can increase the likelihood of the disease occurrence including a genetic factor, human leukocyte antigen HLA-B51 (B51) antigen, infectious conditions such as herpes simplex virus (HSV), those involved in inflammatory and autoimmune conditions such as imbalance of various cytokines and immune cells levels as well as existence of various gene variants. Among the various immuno dysfunctions that are found in BD, patients have increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin-10 (IL-10). Since vasculitis and tissue damage is usually seen with Behcet disease, unusual concentrations of chemokine and adhesion molecules can also help us understand the causes of disease. Among the functional deficiencies of the immune system, increased concentrations of neutrophils and monocytes are of importance leading to an increase in reactive oxygen species (ROS)...

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APA: Copy

SALMANINEJAD, ARASH, SHARIATIZI, SAJJAD, ZAMANI, MOHAMMAD REZA, & SHAKOORI, ABBAS. (2019). Immunology of Behcet disease: review article. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 77(10 ), 605-614. SID. https://sid.ir/paper/406660/en

Vancouver: Copy

SALMANINEJAD ARASH, SHARIATIZI SAJJAD, ZAMANI MOHAMMAD REZA, SHAKOORI ABBAS. Immunology of Behcet disease: review article. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;77(10 ):605-614. Available from: https://sid.ir/paper/406660/en

IEEE: Copy

ARASH SALMANINEJAD, SAJJAD SHARIATIZI, MOHAMMAD REZA ZAMANI, and ABBAS SHAKOORI, “Immunology of Behcet disease: review article,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 77, no. 10 , pp. 605–614, 2019, [Online]. Available: https://sid.ir/paper/406660/en

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