EVALUATION OF LIPID PROFILE AND OXIDATIVE STRESS INDICES IN SERUM AND LIVER OF RAT AFTER IRON-OXIDE NANOPARTICLE ADMINISTRATION

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MOSLEMI N.; NAJAFZADEH H.; KOOCHAK M.; SHAHRIARY A.

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Journal: Feyz Medical Sciences Journal Year:2013 | Volume:17 | Issue:3 Page(s): 247-254

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Title

EVALUATION OF LIPID PROFILE AND OXIDATIVE STRESS INDICES IN SERUM AND LIVER OF RAT AFTER IRON-OXIDE NANOPARTICLE ADMINISTRATION

Author(s)

MOSLEMI N. | NAJAFZADEH H. | KOOCHAK M. | SHAHRIARY A. | Issue Writer Certificate

Keywords

NANO IRON-OXIDEQ2

OXIDATIVE STRESSQ2

LIPID PROFILEQ1

RATQ2

Abstract

Background: Considering the importance of iron and the role of OXIDATIVE STRESS in its toxicity, the purpose of this study was to compare the effect of NANO IRON-OXIDE on OXIDATIVE STRESS indices and LIPID PROFILE in serum and liver of RATs.Materials and Methods: In this experimental study, 15 RATs were allocated into 3 groups; the control and the other two groups were interaperitoneally received either nano or conventional iron-oxide (8mg/kg) daily for 15 days. The amount of malondialdehyde (MDA), antioxidant activity (AOA), triglyceride (TG) and cholesterol in serum and liver; carbonyl protein and total lipid in liver and LDL, VLDL and HDL in serum of RATs were determined.Results: Liver AOA was significantly increased by nano and conventional iron-oxide (P=0.02). MDA in serum was significantly decreased (P=0.001), but in liver increased (P=0.04) in the group received NANO IRON-OXIDE compared with the other two groups. Moreover, carbonyl protein was significantly increased by nano and conventional iron-oxide (P=0.05). TG and VLDL levels were decreased but LDL was increased by nano and conventional iron-oxide (P=0.02).Conclusion: According to the results of the study, NANO IRON-OXIDE can increase OXIDATIVE STRESS in liver and induce arthrosclerosis.

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APA: Copy

MOSLEMI, N., NAJAFZADEH, H., KOOCHAK, M., & SHAHRIARY, A.. (2013). EVALUATION OF LIPID PROFILE AND OXIDATIVE STRESS INDICES IN SERUM AND LIVER OF RAT AFTER IRON-OXIDE NANOPARTICLE ADMINISTRATION. FEYZ, 17(3), 247-254. SID. https://sid.ir/paper/40728/en

Vancouver: Copy

MOSLEMI N., NAJAFZADEH H., KOOCHAK M., SHAHRIARY A.. EVALUATION OF LIPID PROFILE AND OXIDATIVE STRESS INDICES IN SERUM AND LIVER OF RAT AFTER IRON-OXIDE NANOPARTICLE ADMINISTRATION. FEYZ[Internet]. 2013;17(3):247-254. Available from: https://sid.ir/paper/40728/en

IEEE: Copy

N. MOSLEMI, H. NAJAFZADEH, M. KOOCHAK, and A. SHAHRIARY, “EVALUATION OF LIPID PROFILE AND OXIDATIVE STRESS INDICES IN SERUM AND LIVER OF RAT AFTER IRON-OXIDE NANOPARTICLE ADMINISTRATION,” FEYZ, vol. 17, no. 3, pp. 247–254, 2013, [Online]. Available: https://sid.ir/paper/40728/en

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