Comparison of Immunization of Iran s Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice

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MIRZAEE M.; HAGHIGHAT S.; MAHDAVI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Pathobiology Research Year:2018 | Volume:21 | Issue:1 Page(s): 15-21

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Title

Comparison of Immunization of Iran s Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice

Author(s)

MIRZAEE M. | HAGHIGHAT S. | MAHDAVI M. | Issue Writer Certificate

Keywords

Alum AdjuvantQ1

Montanide 720Q1

Hepatitis B VaccineQ2

Fendrix VaccineQ1

Abstract

Aims Vaccination is the only approach to prevent hepatitis B virus infection, But some people do not get a good immune response to the commercial Hepatitis B Vaccine. The purpose of the present study was to compare the immunization of Iran’ s Hepatitis B Vaccine, vaccine formulated in montanide ISA 720 adjuvant and Fendrix Vaccine from GSK company on the Balb/c mice. Materials & Methods In this experimental study, 54 female inbred Balb/c mice were injected in three different formulations of vaccine subcutaneously with two-week intervals. Quantitative amount of IFN-γ , IL-4, and IL-2 cytokines and the IFN-γ /IL-4 ratio from spleen cell culture Supernatant and the anti-HBs Ag antibody level After each injection withBlood sampling were evaluated by ELISA method. Data were analyzed by Graphpad prism 6. 1 software via one way analysis of variance. Findings The vaccine recipient groups did not show significant differences in IFN-γ , IL-2 cytokines and IFN-γ / IL-4 ratio (p>0. 05). Iranian commercial vaccine significantly increased the cytokine IL-4 in comparison with the Fendrix and HBs-MON720 groups (p<0. 05). Antibody responses after the first and second injection of Fendrix and HBs-MON720 showed a significant increase in comparison with the HBS-ALUM group (p<0. 05), but no significant difference was observed after the third injection (p>0. 05). Conclusion Cytokine responses in The Fendrix Vaccine and HBs-MON720 vaccine are partly similar to the Iran’ s Hepatitis B Vaccine but after two injections, Fendrix and HBs-MON720 vaccine showed a higher antibody response.

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APA: Copy

MIRZAEE, M., HAGHIGHAT, S., & MAHDAVI, M.. (2018). Comparison of Immunization of Iran s Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 21(1 ), 15-21. SID. https://sid.ir/paper/407406/en

Vancouver: Copy

MIRZAEE M., HAGHIGHAT S., MAHDAVI M.. Comparison of Immunization of Iran s Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2018;21(1 ):15-21. Available from: https://sid.ir/paper/407406/en

IEEE: Copy

M. MIRZAEE, S. HAGHIGHAT, and M. MAHDAVI, “Comparison of Immunization of Iran s Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 21, no. 1 , pp. 15–21, 2018, [Online]. Available: https://sid.ir/paper/407406/en

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