EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE, FSH, LH AND HISTOLOGICAL CHANGES IN TESTIS IN ADULT MALE RAT

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MOKHTARI M.; SHARIATIE M.; TAVAKOLI F.

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Title

EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE, FSH, LH AND HISTOLOGICAL CHANGES IN TESTIS IN ADULT MALE RAT

Author(s)

MOKHTARI M. | SHARIATIE M. | TAVAKOLI F. | Issue Writer Certificate

Keywords

FLUVOXAMINEQ2

TESTOSTERONEQ2

FSHQ2

LHQ2

TESTESQ2

RATQ2

Abstract

Background: FLUVOXAMINE is a serotonin reuptake inhibitor, considering the importance of this drug in treating nervous disease such as obsessive-compulsive is order, bulimia nervousa, panic disorders and depression, Its side effect on the endocrineaxis are very importante. In the present research the effect of FLUVOXAMINE on the concentrations of LH, FSH, TESTOSTERONE and spermatogenesis was studied.Materials and Methods: The experiments were done on 50 male wistar RATs. The control group received nothing while the sham groups were given 0.05mlof ethanol dissolved in 0.15 ml of distilled water. The experimental group was injected 15, 30, 60mg/kg of drug intraperitoneally for 14 days. Blood samples were taken at 14th day and concentrations of lutein hormone (LH), follicle stimulating hormone (FSH) and TESTOSTERONE were measured by RIA method. In addition, at the 14th day the testis was separated and histological changes were studied among experimental, control and sham groups. The results were evaluated using ANOVA and Duncan test.Results: The results indicated that the concentration of TESTOSTERONE significantly decreas at high doses of FLUVOXAMINE in comparison to the control group. No significant change was observed in the concentration of LH and FSH in experimental groups. Spermatogenesis chain did not show significant difference in the experimental group compared with the control group. Conclusion: According to our findin's FLUVOXAMINE may decreases the concentration of TESTOSTERONE through lowering LH receptors in leydig cells.

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APA: Copy

MOKHTARI, M., SHARIATIE, M., & TAVAKOLI, F.. (2007). EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE, FSH, LH AND HISTOLOGICAL CHANGES IN TESTIS IN ADULT MALE RAT. FEYZ, 10(4 (SERIAL 40)), 31-36. SID. https://sid.ir/paper/40804/en

Vancouver: Copy

MOKHTARI M., SHARIATIE M., TAVAKOLI F.. EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE, FSH, LH AND HISTOLOGICAL CHANGES IN TESTIS IN ADULT MALE RAT. FEYZ[Internet]. 2007;10(4 (SERIAL 40)):31-36. Available from: https://sid.ir/paper/40804/en

IEEE: Copy

M. MOKHTARI, M. SHARIATIE, and F. TAVAKOLI, “EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE, FSH, LH AND HISTOLOGICAL CHANGES IN TESTIS IN ADULT MALE RAT,” FEYZ, vol. 10, no. 4 (SERIAL 40), pp. 31–36, 2007, [Online]. Available: https://sid.ir/paper/40804/en

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