THE EFFECT OF INTRATHECAL ADMINISTRATION OF GENIPIN ON RAT PAW INFLAMMATORY EDEMA IN THE PRESENCE AND ABSENCE OF MORPHINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABBASI Z.; FEREIDONI M.; BEHNAM RASOULI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2014 | Volume:18 | Issue:4 Page(s): 345-353

Download Full-Text

Persian Verion

View:

696

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF INTRATHECAL ADMINISTRATION OF GENIPIN ON RAT PAW INFLAMMATORY EDEMA IN THE PRESENCE AND ABSENCE OF MORPHINE

Author(s)

ABBASI Z. | FEREIDONI M. | BEHNAM RASOULI M. | Issue Writer Certificate

Keywords

UCP2Q2

GENIPINQ2

INFLAMMATIONQ2

MORPHINEQ3

Abstract

Background: Uncoupling protein 2 (UCP2) is an intramembranous mitochondrial protein that the knocking down of its gene causes an induction of the pro-inflammatory responses. However, GENIPIN, as a pharmacological inhibitor of UCP2, has anti-inflammatory effects. In this study the effect of GENIPIN on rat paw inflammatory edema induced by formalin in the presence and absence of MORPHINE was investigated.Materials and Methods: In this research, male Wistar rats (200-250g) were assigned to seven groups: Saline(i.p)-Saline(i.t), Saline(i.p)-DMSO(i.t), Saline(i.p)-genipin(i.t), MORPHINE (10 mg/kg,i.p)-DMSO(i.t), MORPHINE (10mg/kg,i.p)-genipin(i.t), MORPHINE (1mg/kg, i.p)-DMSO (i.t) and MORPHINE (1mg/kg, i.p)-genipin(i.t). INFLAMMATION was induced in the rat’s hind paw by the injection of 50 ml of formalin 2.5% and paw volume was measured using plethysmometer method before and after the injection.Results: Results revealed an anti-inflammatory effect for GENIPIN against the formalininduced paw edema (P<0.001). GENIPIN potentiated the anti-inflammatory effects of MORPHINE, whereas it had no effect on pro-inflammatory effects of low dose of MORPHINE; this dose of MORPHINE reversed the anti-inflammatory effects of GENIPIN.Conclusion: Although GENIPIN, a UCP2 inhibitor, was expected to increase the inflammatory edema, but probably its anti-inflammatory effects via the NF-kB inhibition is so robust that can cover its inhibitory effect on UCP2 and the subsequent INFLAMMATION. The anti-inflammatory effect of MORPHINE was set in the range of anti-inflammatory effects of GENIPIN. The finding that the anti-inflammatory effect of GENIPIN is attenuated at the presence of ultra-low dose MORPHINE may be due to their common mechanisms which suggest further research on KATP channels.

Cites

No record.

References

No record.

Cite

APA: Copy

ABBASI, Z., FEREIDONI, M., & BEHNAM RASOULI, M.. (2014). THE EFFECT OF INTRATHECAL ADMINISTRATION OF GENIPIN ON RAT PAW INFLAMMATORY EDEMA IN THE PRESENCE AND ABSENCE OF MORPHINE. FEYZ, 18(4), 345-353. SID. https://sid.ir/paper/40830/en

Vancouver: Copy

ABBASI Z., FEREIDONI M., BEHNAM RASOULI M.. THE EFFECT OF INTRATHECAL ADMINISTRATION OF GENIPIN ON RAT PAW INFLAMMATORY EDEMA IN THE PRESENCE AND ABSENCE OF MORPHINE. FEYZ[Internet]. 2014;18(4):345-353. Available from: https://sid.ir/paper/40830/en

IEEE: Copy

Z. ABBASI, M. FEREIDONI, and M. BEHNAM RASOULI, “THE EFFECT OF INTRATHECAL ADMINISTRATION OF GENIPIN ON RAT PAW INFLAMMATORY EDEMA IN THE PRESENCE AND ABSENCE OF MORPHINE,” FEYZ, vol. 18, no. 4, pp. 345–353, 2014, [Online]. Available: https://sid.ir/paper/40830/en

Related Journal Papers