THE EFFECT OF INDOMETHACIN ON PENTYLENETETRAZOLE-INDUCED KINDLING IN MALE RATS

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DAGHIGH F.; NOUREDDINI M.; TAKHTEFIROUZEH M.; HEYDARI A.

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Journal Paper

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Journal: Feyz Medical Sciences Journal Year:2014 | Volume:18 | Issue:4 Page(s): 286-291

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Title

THE EFFECT OF INDOMETHACIN ON PENTYLENETETRAZOLE-INDUCED KINDLING IN MALE RATS

Author(s)

DAGHIGH F. | NOUREDDINI M. | TAKHTEFIROUZEH M. | HEYDARI A. | Issue Writer Certificate

Keywords

KINDLINGQ2

CYCLOOXYGENASEQ2

INDOMETHACINQ3

PENTYLENETETRAZOLEQ2

Abstract

Background: CYCLOOXYGENASE, the rate-limiting enzyme in prostaglandin synthesis, exists as two isoforms, CYCLOOXYGENASE-1 and CYCLOOXYGENASE-2. Previous studies have shown the protective effect of CYCLOOXYGENASE enzyme in the development of convulsion. However, the involvement of CYCLOOXYGENASE-1 in the pathogenesis of epilepsy has not well known. The present study was designed to explore whether INDOMETHACIN (a nonspecific COX inhibitor) can affect PENTYLENETETRAZOLE (PTZ)-induced KINDLING in rats.Materials and Methods: KINDLING, as a chronic model of epilepsy, was inducted by the intraperitoneal injection of PTZ (37.5 mg/kg) every 48 hours (13 times) in all groups. In the pre-treatment groups, intraperitoneal injection of INDOMETHACIN (2.5, 5, 10 mg/kg) was done 20 min before each PTZ injection. In sham group, tween (20%) was used as a solvent.Results: Repeated injections of PTZ after 13 sessions significantly induced the KINDLING in the control group. In pre-treatment groups, INDOMETHACIN (2.5, 5, 10 mg/kg) significantly decreased PTZ-induced mean KINDLING scores.Conclusion: The finding that the INDOMETHACIN can partially reverse the KINDLING mean scores in rat indicates the involvement of cycloogygenase-1 isoform. It seems that cycloogygenase-1 inhibitors could be a useful choice for the treatment of epilepsy.

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APA: Copy

DAGHIGH, F., NOUREDDINI, M., TAKHTEFIROUZEH, M., & HEYDARI, A.. (2014). THE EFFECT OF INDOMETHACIN ON PENTYLENETETRAZOLE-INDUCED KINDLING IN MALE RATS. FEYZ, 18(4), 286-291. SID. https://sid.ir/paper/40833/en

Vancouver: Copy

DAGHIGH F., NOUREDDINI M., TAKHTEFIROUZEH M., HEYDARI A.. THE EFFECT OF INDOMETHACIN ON PENTYLENETETRAZOLE-INDUCED KINDLING IN MALE RATS. FEYZ[Internet]. 2014;18(4):286-291. Available from: https://sid.ir/paper/40833/en

IEEE: Copy

F. DAGHIGH, M. NOUREDDINI, M. TAKHTEFIROUZEH, and A. HEYDARI, “THE EFFECT OF INDOMETHACIN ON PENTYLENETETRAZOLE-INDUCED KINDLING IN MALE RATS,” FEYZ, vol. 18, no. 4, pp. 286–291, 2014, [Online]. Available: https://sid.ir/paper/40833/en

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