COMPARISON OF HYDROXYZINE, CETIRIZINE AND DOXEPIN IN TREATMENT OF CHRONIC PRURITUS DUE TO SULFUR MUSTARD

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SHOHRATI M.; DAVOUDI SEYED MASOUD; SADR S.B.; KESHAVARZ S.; SEYFI M.; NAGHIZADEH JAHROMI M.M.

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Journal: JOURNAL OF MILITARY MEDICINE Year:2006 | Volume:8 | Issue:2 (28) Page(s): 134-139

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Title

COMPARISON OF HYDROXYZINE, CETIRIZINE AND DOXEPIN IN TREATMENT OF CHRONIC PRURITUS DUE TO SULFUR MUSTARD

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Keywords

PRURITUSQ4

SULFUR MUSTARDQ3

HYDOXYZINEQ3

CETIRIZINEQ3

DOXEPINQ3

Abstract

Introduction: Chronic PRURITUS, as one of the most prevalent complications in enormous SULFUR MUSTARD victims, can lead to long term disability. Due to side effects and low efficacy of long term therapy with some drugs, like corticosteroids, or low efficacy of some others like first generation anti-histamines, we decided to compare the efficacy and side effects of CETIRIZINE, Hydroxizine and DOXEPIN.Materials and Methods: This randomized double-blind study was done on 75 veterans in Baqiyatallah (a.s.) hospital during 2005. PRURITUS Score (PS) and Visual Analysis Score (VAS) were measured for all patients before initiating the treatment. Patients were randomly divided into three 25 groups: group one received DOXEPIN capsule, 10 mg/day; group two received tablet of Hydroxyzine 25 mg/day; and the third group received CETIRIZINE tablet 10 mg/day for one month.After one month treatment and also one month follow up, PRURITUS indecies were measured again and compared with the first day scores.Results: Patients in all three groups had significant decreases in their PS and VAS after one month therapy (P<0.05), but in most of them, the indecies returned to the base score after one month follow up. 18 veterans in Hydroxyzine group, 14 in DOXEPIN, and 6 patients in CETIRIZINE group suffered from sedation, as drug side effects. In conclusion, HYDOXYZINE and DOXEPIN had neady the same efficacy (p>0.05) in decreasing of PRURITUS scores, while CETIRIZINE, although causeda significant (P<0.05) decline, but it was not as much as the formers.Discussion: Both DOXEPIN and Hydroxyzine had nearly the same efficacy, but considering that DOXEPIN had lower adverse effects than Hydroxyzine, we think that it is a better choice to treat PRURITUS of veterans.

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APA: Copy

SHOHRATI, M., DAVOUDI, SEYED MASOUD, SADR, S.B., KESHAVARZ, S., SEYFI, M., & NAGHIZADEH JAHROMI, M.M.. (2006). COMPARISON OF HYDROXYZINE, CETIRIZINE AND DOXEPIN IN TREATMENT OF CHRONIC PRURITUS DUE TO SULFUR MUSTARD. JOURNAL OF MILITARY MEDICINE, 8(2 (28)), 134-139. SID. https://sid.ir/paper/408335/en

Vancouver: Copy

SHOHRATI M., DAVOUDI SEYED MASOUD, SADR S.B., KESHAVARZ S., SEYFI M., NAGHIZADEH JAHROMI M.M.. COMPARISON OF HYDROXYZINE, CETIRIZINE AND DOXEPIN IN TREATMENT OF CHRONIC PRURITUS DUE TO SULFUR MUSTARD. JOURNAL OF MILITARY MEDICINE[Internet]. 2006;8(2 (28)):134-139. Available from: https://sid.ir/paper/408335/en

IEEE: Copy

M. SHOHRATI, SEYED MASOUD DAVOUDI, S.B. SADR, S. KESHAVARZ, M. SEYFI, and M.M. NAGHIZADEH JAHROMI, “COMPARISON OF HYDROXYZINE, CETIRIZINE AND DOXEPIN IN TREATMENT OF CHRONIC PRURITUS DUE TO SULFUR MUSTARD,” JOURNAL OF MILITARY MEDICINE, vol. 8, no. 2 (28), pp. 134–139, 2006, [Online]. Available: https://sid.ir/paper/408335/en

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