THE COMPARISON OF EFFICACY OF TWO AND THREE-WEEK PREDNISOLONE THERAPY IN PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA

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ANOUSHIRVANI A.A.; MOSHFEGHI K.; RAFIEE M.; BAKHSHI S.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:15 | Issue:15 (67) Page(s): 0-0

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Title

THE COMPARISON OF EFFICACY OF TWO AND THREE-WEEK PREDNISOLONE THERAPY IN PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA

Author(s)

ANOUSHIRVANI A.A. | MOSHFEGHI K. | RAFIEE M. | BAKHSHI S. | Issue Writer Certificate

Keywords

PREDNISOLONEQ2

IMMUNE THROMBOCYTOPENIC PURPURAQ2

PLATELETQ2

Abstract

Background: IMMUNE THROMBOCYTOPENIC PURPURAis an acquired disorder. Conventional treatment of IMMUNE THROMBOCYTOPENIC PURPURAincludes PREDNISOLONE (1mg/kg/day). Customarily, steroidsareadministered for about 3-6 weeks, however,steroids have several side effects. The aim of this study was to compare the efficacy of two and three-week PREDNISOLONE therapy in patients with IMMUNE THROMBOCYTOPENIC PURPURAMaterials and Methods: In this randomized clinical trial, 66 patients with confirmed IMMUNE THROMBOCYTOPENIC PURPURA who had referred to Khansari Hospital, Arak, were randomly selected and administered PREDNISOLONE (1mg/kg/day) for two and three weeks alternatively. Patients' PLATELET count and complications associated with the treatment (diabetes and hypertension) were compared. Results: At the end of the treatment course, there was not a significant difference in mean PLATELET count between the two groups (p=0.748). Side effects in two and three-week protocols were 15.2% and 18.2%, respectively, however, distribution of the complications (side effect) in the two groups was equal (p=0.9). Conclusion: Considering the absence of significant differences in mean PLATELET count between the two groups at the end of the two treatment protocols and the higherpercentage of side effects in the patients that had received the three-week PREDNISOLONE therapy protocol, it seems that the two-week course of IMMUNE THROMBOCYTOPENIC PURPURA treatment is as effective as the three-week protocol.

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APA: Copy

ANOUSHIRVANI, A.A., MOSHFEGHI, K., RAFIEE, M., & BAKHSHI, S.. (2013). THE COMPARISON OF EFFICACY OF TWO AND THREE-WEEK PREDNISOLONE THERAPY IN PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(15 (67)), 0-0. SID. https://sid.ir/paper/408542/en

Vancouver: Copy

ANOUSHIRVANI A.A., MOSHFEGHI K., RAFIEE M., BAKHSHI S.. THE COMPARISON OF EFFICACY OF TWO AND THREE-WEEK PREDNISOLONE THERAPY IN PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;15(15 (67)):0-0. Available from: https://sid.ir/paper/408542/en

IEEE: Copy

A.A. ANOUSHIRVANI, K. MOSHFEGHI, M. RAFIEE, and S. BAKHSHI, “THE COMPARISON OF EFFICACY OF TWO AND THREE-WEEK PREDNISOLONE THERAPY IN PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 15 (67), pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/408542/en

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