Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Antinarcotic Police Dogs (German shepherd)

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Shahrokhi Saboor Navid; GhorbanNejad Ali Asghar

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Journal: Police Cultural Studies Year:2021 | Volume:7 | Issue:4 (27) Page(s): 55-66

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Information Journal Paper

Title

Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Antinarcotic Police Dogs (German shepherd)

Author(s)

Shahrokhi Saboor Navid | GhorbanNejad Ali Asghar | Issue Writer Certificate

Keywords

Curcumin

Mebendazole

German shepherd

AntiNarcotics Police

Abstract

The aim of this study was to evaluate the therapeutic and prophylactic effects of Curcumin on acute hepatotoxicity induced by Mebendazole administration in German shepherd dogs. In this study, 20 dogs were randomly divided into 4 groups. Group A dogs received daily 150 mg / kg of Mebendazole orally and in a gelatin capsule with food. Group B dogs received daily 500 mg / kg Curcumin and 150 mg / kg Mebendazole orally and in gelatin capsules with food. Dogs in groups C and D were treated similar to group 2, except that they received Curcumin 2 and 24 hours after taking Mebendazole, respectively. ALT, AST, ALP and LDH enzymes were measured in all groups. In group A dogs, serum concentrations of ALT, AST, ALP and LDH enzymes increased significantly after 24 hours (P <0. 05). Enzyme levels decreased in groups B, C and D but their effect were significant only in group D and the concentration of enzymes was in the normal range (P <0. 05). The results of this study showed that Curcumin has significant therapeutic effects against acute hepatotoxicity due to Mebendazole administration.

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APA: Copy

Shahrokhi Saboor, Navid, & GhorbanNejad, Ali Asghar. (2021). Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Antinarcotic Police Dogs (German shepherd). JOURNALS OF HAMEDAN POLICE SCIENCE, 7(4 (27) ), 55-66. SID. https://sid.ir/paper/408994/en

Vancouver: Copy

Shahrokhi Saboor Navid, GhorbanNejad Ali Asghar. Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Antinarcotic Police Dogs (German shepherd). JOURNALS OF HAMEDAN POLICE SCIENCE[Internet]. 2021;7(4 (27) ):55-66. Available from: https://sid.ir/paper/408994/en

IEEE: Copy

Navid Shahrokhi Saboor, and Ali Asghar GhorbanNejad, “Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Antinarcotic Police Dogs (German shepherd),” JOURNALS OF HAMEDAN POLICE SCIENCE, vol. 7, no. 4 (27) , pp. 55–66, 2021, [Online]. Available: https://sid.ir/paper/408994/en

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