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Information Journal Paper

Title

High intensity interval training leads to protein synthesis through the complex pathway of a target of rapamycin (mTORC1) in the heart muscle tissue of a type 1 diabetic rats.

Pages

  47-54

Abstract

 Introduction: The complex pathway of a rapamycin target in mammals (mTORC1) is one of the important pathways in protein synthesis in the heart, which in type 1diabetes can led to impairment and is a factor for hypertrophy. The aim of this study is to investigate the effect of high intensity interval training (HIIT) on the mTORC1 Pathway in Heart Muscle tissue of type 1 diabetic rats. Materials and Methods: In this experimental study, 16 Sprague-Dawley male rats (with mean weight of 300± 20 gr) were selected and after induction of diabetes by STZ and nicotinamide were randomly assigned into two groups: diabetic training (8 head) and diabetic control (8 head). The experimental group performed 4 days a week the exercise training for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data. Results: There was a significant increase in the content of AKT1 (p<0. 027), mTOR (p<0. 003) and P70S6K1 (p<0. 024) proteins in the training group compared to control group, while significant change was not observed in the content of 4EBP1 (p<0. 75) in the training group compared to control group. Conclusion: HIIT for 4 weeks can activate the pathway AKT1/mTOR/P70S6K1 on the mTORC1 Pathway. Therefore, HIIT by this pathway could lead to physiologic hypertrophy in the heart of type 1 diabetic subjects.

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    APA: Copy

    AGHAEI BAHMANBEGLOU, NEDA, SHERAFATI MOGHADAM, MOHAMMAD, DARYANOOSH, FARHAD, Shadmehri, Saeedeh, & JAHANI GOLBAR, SHIVA. (2021). High intensity interval training leads to protein synthesis through the complex pathway of a target of rapamycin (mTORC1) in the heart muscle tissue of a type 1 diabetic rats.. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 28(1 ), 47-54. SID. https://sid.ir/paper/409219/en

    Vancouver: Copy

    AGHAEI BAHMANBEGLOU NEDA, SHERAFATI MOGHADAM MOHAMMAD, DARYANOOSH FARHAD, Shadmehri Saeedeh, JAHANI GOLBAR SHIVA. High intensity interval training leads to protein synthesis through the complex pathway of a target of rapamycin (mTORC1) in the heart muscle tissue of a type 1 diabetic rats.. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(1 ):47-54. Available from: https://sid.ir/paper/409219/en

    IEEE: Copy

    NEDA AGHAEI BAHMANBEGLOU, MOHAMMAD SHERAFATI MOGHADAM, FARHAD DARYANOOSH, Saeedeh Shadmehri, and SHIVA JAHANI GOLBAR, “High intensity interval training leads to protein synthesis through the complex pathway of a target of rapamycin (mTORC1) in the heart muscle tissue of a type 1 diabetic rats.,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 1 , pp. 47–54, 2021, [Online]. Available: https://sid.ir/paper/409219/en

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