The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial

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ESKANDARI P.; POULADI SH.; ANVARIPOUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian South Medical Journal Year:2021 | Volume:23 | Issue:6 Page(s): 528-540

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Title

The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial

Author(s)

ESKANDARI P. | POULADI SH. | ANVARIPOUR A. | Issue Writer Certificate

Keywords

Vitamin CQ2

Inflammatory markersQ1

Atrial fibrillationQ2

Coronary artery bypass surgeryQ1

Abstract

Background: Coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass pump may cause systemic inflammatory reactions by releasing cytokines which leads to multiple organ failure. Vitamin C has anti-inflammatory and antioxidant properties. The study aimed to determine the effect of Vitamin C on Inflammatory markers and Atrial fibrillation in patients undergoing CABG. Materials and Methods: In the present single-blind randomized controlled clinical trial, 80 patients were divided to experimental and control groups. The experimental group received Vitamin C 2 g IV, and the control group received the same amount (equivalent to 4×5 cc shots) of normal saline IV 10 minutes after induction of anesthesia. Arterial blood samples were taken at specified intervals to assess IL-6 and hsCRP levels. The data were analyzed in SPSS-24. Results: The changes in IL-6 values at the specific intervals were not statistically significant (P> 0. 05). Significant differences were observed in hsCRP levels only 24 hours after CABG. The incidence of Atrial fibrillation was not significantly different between the two groups after the intervention. Conclusion: This study showed that ascorbic acid has no effect on reducing IL6 and hsCRP levels in patients undergoing CABG, and similarly, does not cause a reduction in post-CABG Atrial fibrillation.

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APA: Copy

ESKANDARI, P., POULADI, SH., & ANVARIPOUR, A.. (2021). The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 23(6 ), 528-540. SID. https://sid.ir/paper/409402/en

Vancouver: Copy

ESKANDARI P., POULADI SH., ANVARIPOUR A.. The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2021;23(6 ):528-540. Available from: https://sid.ir/paper/409402/en

IEEE: Copy

P. ESKANDARI, SH. POULADI, and A. ANVARIPOUR, “The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 23, no. 6 , pp. 528–540, 2021, [Online]. Available: https://sid.ir/paper/409402/en

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