THE EFFECTS OF TOPICAL CLOBETASOL AND DOXEPIN VERSUS CLOBETASOL ALONE IN TREATMENT OF HAND ECZEMA

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DEHGHANI F.; MIRZADEH S.M.; BABAEI A.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:7 (76) Page(s): 12-19

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Title

THE EFFECTS OF TOPICAL CLOBETASOL AND DOXEPIN VERSUS CLOBETASOL ALONE IN TREATMENT OF HAND ECZEMA

Author(s)

DEHGHANI F. | MIRZADEH S.M. | BABAEI A. | Issue Writer Certificate

Keywords

CLOBETASOLQ2

DOXEPINQ2

ECZEMAQ2

THERAPYQ3

Abstract

Background: Hand ECZEMA is a common skin disease that often needs long term treatment. There are several reports about the efficacy of topical DOXEPIN in treatment of pruritic dermal diseases. The aim of this study was to compare the efficacy of 5% DOXEPIN cream and CLOBETASOL 0.05% versus CLOBETASOL 0.05% alone in treatment of hand ECZEMA.Materials and Methods: In this clinical trial study, 70 patients with moderate to severe hand dermatitis in 2011-12 were selected and randomly divided to two groups to be treated with either the DOXEPIN 5% cream and CLOBETASOL or CLOBETASOL and placebo cream twice daily for 8 days. Efficacy assessments were performed at baseline and 8days after termination of THERAPY, according to hand ECZEMA severity index (HECSI) and visual analogue scale (VAS). Statistical analysis was done using SPSS software, version 18.0 and statistical tests including paired T-test and independent T-test.Results: Overall, 56 patients completed our study (32 males and 24 females). The HECSI score and VAS significantly reduced in both groups (p£0.05), but differences in HECSI and VAS reduction between groups were not significant.Conclusion: Although there are some evidence on effectiveness of DOXEPIN 5% cream on reducing the signs and symptoms of ECZEMAtous dermatitis, few trials have been performed. We suggest that the efficacy of this treatment against chronic hand dermatitis be evaluated in a more extensive clinical trial.

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APA: Copy

DEHGHANI, F., MIRZADEH, S.M., & BABAEI, A.. (2013). THE EFFECTS OF TOPICAL CLOBETASOL AND DOXEPIN VERSUS CLOBETASOL ALONE IN TREATMENT OF HAND ECZEMA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(7 (76)), 12-19. SID. https://sid.ir/paper/409452/en

Vancouver: Copy

DEHGHANI F., MIRZADEH S.M., BABAEI A.. THE EFFECTS OF TOPICAL CLOBETASOL AND DOXEPIN VERSUS CLOBETASOL ALONE IN TREATMENT OF HAND ECZEMA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(7 (76)):12-19. Available from: https://sid.ir/paper/409452/en

IEEE: Copy

F. DEHGHANI, S.M. MIRZADEH, and A. BABAEI, “THE EFFECTS OF TOPICAL CLOBETASOL AND DOXEPIN VERSUS CLOBETASOL ALONE IN TREATMENT OF HAND ECZEMA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 7 (76), pp. 12–19, 2013, [Online]. Available: https://sid.ir/paper/409452/en

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