PRODUCTION AND PHYSICOCHEMICAL EVALUATION OF NANO-SIZED LAMIVUDINE LOADED PEGYLATED CHITOSAN

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HEYDARI HOSSEIN; SHAFIEE ARDESTANI MEHDI; ZABIHOLLAHI REZVAN; SADAT SEYED MEHDI; IRANI SHIVA; HOSEINI SEYED NEZAMEDDIN; AMINI SAFIEH; SIADAT SEYED DAVAR; KHOSRAVI MOHAMMAD SADEGH; AZIZI SARAJI ALIREZA; RAHIMI POONEH; HEKMAT SOHEILA; AGHASADEGHI MOHAMMAD REZA

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:6 (75) Page(s): 52-64

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Title

PRODUCTION AND PHYSICOCHEMICAL EVALUATION OF NANO-SIZED LAMIVUDINE LOADED PEGYLATED CHITOSAN

Author(s)

Keywords

ANTI-HIVAGENTQ2

CHITOSANQ2

LAMIVUDINEQ2

POLYETHYLENE GLYCOLSQ2

Abstract

Background: Due to the lack of efficient anti-HIV vaccine, anti-HIV pharmaceuticals play an important role in controlling HIV infection. Also significant rise in drug resistance and drug toxicity has caused increased interest in finding new anti-HIV agents. In this study, a nano-sized version of LAMIVUDINE based on PEGylated CHITOSAN was synthesized.Materials and Methods: In this research, nanoparticles of CHITOSAN were efficiently PEGylated for increasing their stability in water and then the anti-HIV drug, LAMIVUDINE, was loaded on these PEGylated nanoparticles. After purification and lyophilization of new synthesized nanoparticle, the raw materials and final product were sampled and FTIR, HNMR and CHN analyses were done.Results: Results of HNMR spectroscopy showed that CHITOSAN nanoparticle was successfully PEGylated. HNMR data confirmed FTIR results and indicated that LAMIVUDINE was conjugated on CHITOSAN nanoparticle. In addition, CHN analysis data also confirmed both HNMR and FTIR data, and demonstrated that a high yield of CHITOSAN nanoparticle PEGylation (approximately 97%) was done and illustrated a high capacity of LAMIVUDINE conjugation on nano-sized PEGylated CHITOSAN (30%W/W CHITOSAN).Conclusion: In this study, LAMIVUDINE drug was successfully synthesized, based on PEGylated CHITOSAN nanoparticle.

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APA: Copy

HEYDARI, HOSSEIN, SHAFIEE ARDESTANI, MEHDI, ZABIHOLLAHI, REZVAN, SADAT, SEYED MEHDI, IRANI, SHIVA, HOSEINI, SEYED NEZAMEDDIN, AMINI, SAFIEH, SIADAT, SEYED DAVAR, KHOSRAVI, MOHAMMAD SADEGH, AZIZI SARAJI, ALIREZA, RAHIMI, POONEH, HEKMAT, SOHEILA, & AGHASADEGHI, MOHAMMAD REZA. (2013). PRODUCTION AND PHYSICOCHEMICAL EVALUATION OF NANO-SIZED LAMIVUDINE LOADED PEGYLATED CHITOSAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(6 (75)), 52-64. SID. https://sid.ir/paper/409466/en

Vancouver: Copy

HEYDARI HOSSEIN, SHAFIEE ARDESTANI MEHDI, ZABIHOLLAHI REZVAN, SADAT SEYED MEHDI, IRANI SHIVA, HOSEINI SEYED NEZAMEDDIN, AMINI SAFIEH, SIADAT SEYED DAVAR, KHOSRAVI MOHAMMAD SADEGH, AZIZI SARAJI ALIREZA, RAHIMI POONEH, HEKMAT SOHEILA, AGHASADEGHI MOHAMMAD REZA. PRODUCTION AND PHYSICOCHEMICAL EVALUATION OF NANO-SIZED LAMIVUDINE LOADED PEGYLATED CHITOSAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(6 (75)):52-64. Available from: https://sid.ir/paper/409466/en

IEEE: Copy

HOSSEIN HEYDARI, MEHDI SHAFIEE ARDESTANI, REZVAN ZABIHOLLAHI, SEYED MEHDI SADAT, SHIVA IRANI, SEYED NEZAMEDDIN HOSEINI, SAFIEH AMINI, SEYED DAVAR SIADAT, MOHAMMAD SADEGH KHOSRAVI, ALIREZA AZIZI SARAJI, POONEH RAHIMI, SOHEILA HEKMAT, and MOHAMMAD REZA AGHASADEGHI, “PRODUCTION AND PHYSICOCHEMICAL EVALUATION OF NANO-SIZED LAMIVUDINE LOADED PEGYLATED CHITOSAN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 6 (75), pp. 52–64, 2013, [Online]. Available: https://sid.ir/paper/409466/en

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