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Information Journal Paper

Title

Deep brain stimulation of the lateral hypothalamic area alters dopamine receptors in the prefrontal cortex of morphine-dependent rats

Pages

  124-131

Abstract

 Background and aims: The Lateral hypothalamus (LH) is a main component of the brain’ s reward circuit. Previous studies have shown that high-frequency Deep brain stimulation (DBS) of the LH prevents Morphine-induced place preference in Rats. In the present study we evaluated the effect of intra-LH DBS on the levels of Dopamine receptors in the prefrontal cortex. Methods: Electrodes were implanted into the LH bilaterally. Rats were allocated to four different groups: Morphine-DBS, saline-DBS, Morphine-sham, and saline-sham. Morphine (5mg/kg. sc) and saline were given in four consecutive days immediately followed by DBS (130 Hz pulse repetition frequency, 150 μ A pulse amplitude, and 100 μ s pulse width) or sham-DBS for 30 min corresponding to the experimental group. One day after the last injection Rats were sacrificed and the prefrontal cortex was dissected for assaying Dopamine receptors and c-fos mRNA expression. Results: Morphine increased D1 receptor, decreased D2 receptor, and had no effect on D3, D4, and D5 receptors. DBS in Morphine-treated Rats prevented the elevation of D1 receptor, increased D2 and D3 receptors, decreased D5 receptor, and had no effect on D4 receptors. Morphine decreased c-fos mRNA levels in the prefrontal cortex and DBS increased it. Conclusion: DBS of LH influenced the brain’ s dopaminergic system particularly in the prefrontal cortex.

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    APA: Copy

    ASHABI, GHORBANGOL, Fattahi, Mojdeh, KARIMIAN, SEYED MORTEZA, & RIAHI, ESMAIL. (2019). Deep brain stimulation of the lateral hypothalamic area alters dopamine receptors in the prefrontal cortex of morphine-dependent rats. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 3(2 (10) ), 124-131. SID. https://sid.ir/paper/409552/en

    Vancouver: Copy

    ASHABI GHORBANGOL, Fattahi Mojdeh, KARIMIAN SEYED MORTEZA, RIAHI ESMAIL. Deep brain stimulation of the lateral hypothalamic area alters dopamine receptors in the prefrontal cortex of morphine-dependent rats. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;3(2 (10) ):124-131. Available from: https://sid.ir/paper/409552/en

    IEEE: Copy

    GHORBANGOL ASHABI, Mojdeh Fattahi, SEYED MORTEZA KARIMIAN, and ESMAIL RIAHI, “Deep brain stimulation of the lateral hypothalamic area alters dopamine receptors in the prefrontal cortex of morphine-dependent rats,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 3, no. 2 (10) , pp. 124–131, 2019, [Online]. Available: https://sid.ir/paper/409552/en

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