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Information Journal Paper

Title

Efficacy of Finasteride in Patients with Bladder Cancer Undergoing Bacillus Calmette-Gué rin Therapy

Pages

  78-86

Keywords

Bacillus Calmette-Guérin (BCG) 

Abstract

 Background and Objective: Despite the widespread use of Bacillus Calmette-Gué rin (BCG) for the treatment of superficial bladder tumors, recurrence and treatment failure is common among a significant proportion of patients. In this regard, the addition of Finasteride to BCG treatment may increase the effectiveness of Bladder cancer treatment. The present study aimed, to assess the effectiveness of Finasteride in patients with Bladder cancer undergoing BCG therapy. Methods: In this retrospective cohort study, 70 men with Bladder cancer who were treated with BCG alone (control group, n=35) and BCG with Finasteride (case group, n=35) in Shahid Beheshti Hospital in Hamadan from 2018 to 2019 were compared in terms of treatment efficacy. Data were analyzed by SPSS software (version 21) at a 95% confidence interval. Results: The mean duration of follow-up was 2. 29± 1. 55 years; moreover, the mean age scores of patients in the case and control groups were reported as 66. 00± 8. 95 and 62. 94± 13. 69 years, respectively (P=0. 273). The frequency rates of recurrence of Bladder cancer in patients receiving BCG with Finasteride and BCG alone were obtained at 17. 1% and 31. 4%, respectively (P=0. 163). The mean recurrence times were 8. 50 and 7. 27 months in the case and control groups, respectively (P=0. 404). Conclusion: The addition of Finasteride tablets to the BCG treatment regimen in patients with Bladder cancer, reduces the cancer recurrence rate.

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    APA: Copy

    Amirzargar, Mohamad Ali, Roostaei Hosein Abadi, Mahzad, Mohsenpour, Mohsen, Norozi Fard, Roghayeh, & Mirtahmasb, Reyhaneh. (2021). Efficacy of Finasteride in Patients with Bladder Cancer Undergoing Bacillus Calmette-Gué rin Therapy. JOURNAL OF RESEARCH IN UROLOGY, 4(2 ), 78-86. SID. https://sid.ir/paper/410859/en

    Vancouver: Copy

    Amirzargar Mohamad Ali, Roostaei Hosein Abadi Mahzad, Mohsenpour Mohsen, Norozi Fard Roghayeh, Mirtahmasb Reyhaneh. Efficacy of Finasteride in Patients with Bladder Cancer Undergoing Bacillus Calmette-Gué rin Therapy. JOURNAL OF RESEARCH IN UROLOGY[Internet]. 2021;4(2 ):78-86. Available from: https://sid.ir/paper/410859/en

    IEEE: Copy

    Mohamad Ali Amirzargar, Mahzad Roostaei Hosein Abadi, Mohsen Mohsenpour, Roghayeh Norozi Fard, and Reyhaneh Mirtahmasb, “Efficacy of Finasteride in Patients with Bladder Cancer Undergoing Bacillus Calmette-Gué rin Therapy,” JOURNAL OF RESEARCH IN UROLOGY, vol. 4, no. 2 , pp. 78–86, 2021, [Online]. Available: https://sid.ir/paper/410859/en

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