STUDY OF CORD BLOOD INSULIN IN RELATION TO MATERNAL BLOOD GLUCOSE IN 75 GRAM ORAL GLUCOSE TOLERANCE TEST

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HEMATYAR MASOUMEH; MAHGOUBI MARJAN; KATAYOUN FADAKI FATEMEH; EMDADI ROYA; SADIGHPOUR MITRA; MOZAFARY REZA

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Journal: Journal of Medical Council of Iran Year:2011 | Volume:29 | Issue:2 Page(s): 162-168

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Title

STUDY OF CORD BLOOD INSULIN IN RELATION TO MATERNAL BLOOD GLUCOSE IN 75 GRAM ORAL GLUCOSE TOLERANCE TEST

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Keywords

INSULINQ2

GESTATIONAL DIABETESQ2

75 GR ORAL GLUCOSE TOLERANCE TESTQ2

MACROSOMIAQ3

Abstract

Background: The INSULIN level of fetus indicates the effects of maternal diabetes on fetus and its health in future. There is not exact glucose threshold in maternal glucose tolerance test (GTT) for fetal hyperINSULINism and its correlation with fetal morbidity and mortality. The aim of this study is to determine the correlation between INSULIN levels in cord blood with maternal blood glucose levels in 75 gram oral GTT.Methods: This is a cohort study on 200 pregnant women in Tehran Javaheri hospital in 2009. The 75 gram OGTT was performed at 24- 28 weeks of gestation and then 2 cc of cord blood for measuring INSULIN was gotten at delivery time. The data analysed by SPSS ver 13 and correlation, regression and independent t test.Results: 5.5% of neonates have hyperINSULINism. The correlation between maternal fasting blood sugar and cord blood INSULIN was significant. The correlation between infant birth weight and cord blood INSULIN and also maternal first hour glucose level in 75 gram OGTT was significant. Although the level of cord blood INSULIN was higher in mothers with impaired GTT but the correlation was not significant.Conclusion: The concentration of INSULIN in fetus indicate the levels of glucose that transfer from mother to fetus intrauterine. In this study the most correlation between hyperINSULINemia with maternal fasting blood sugar was observed. It seems maternal FBS has the most sensitivity for detection of hyperINSULINemia in fetus.

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APA: Copy

HEMATYAR, MASOUMEH, MAHGOUBI, MARJAN, KATAYOUN FADAKI, FATEMEH, EMDADI, ROYA, SADIGHPOUR, MITRA, & MOZAFARY, REZA. (2011). STUDY OF CORD BLOOD INSULIN IN RELATION TO MATERNAL BLOOD GLUCOSE IN 75 GRAM ORAL GLUCOSE TOLERANCE TEST. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 29(2), 162-168. SID. https://sid.ir/paper/41175/en

Vancouver: Copy

HEMATYAR MASOUMEH, MAHGOUBI MARJAN, KATAYOUN FADAKI FATEMEH, EMDADI ROYA, SADIGHPOUR MITRA, MOZAFARY REZA. STUDY OF CORD BLOOD INSULIN IN RELATION TO MATERNAL BLOOD GLUCOSE IN 75 GRAM ORAL GLUCOSE TOLERANCE TEST. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2011;29(2):162-168. Available from: https://sid.ir/paper/41175/en

IEEE: Copy

MASOUMEH HEMATYAR, MARJAN MAHGOUBI, FATEMEH KATAYOUN FADAKI, ROYA EMDADI, MITRA SADIGHPOUR, and REZA MOZAFARY, “STUDY OF CORD BLOOD INSULIN IN RELATION TO MATERNAL BLOOD GLUCOSE IN 75 GRAM ORAL GLUCOSE TOLERANCE TEST,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 29, no. 2, pp. 162–168, 2011, [Online]. Available: https://sid.ir/paper/41175/en

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