Evaluation of CXCL12, CD28 and FOS gene expression in HIV-infected patients with discordance in CD4+T-Cell Levels

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Kolbadi K.; ALIASGARI E.; BAESI K.

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Journal Paper

Paper Information

Journal: Pathobiology Research Year:2021 | Volume:23 | Issue:5 Page(s): 57-63

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Information Journal Paper

Title

Evaluation of CXCL12, CD28 and FOS gene expression in HIV-infected patients with discordance in CD4+T-Cell Levels

Author(s)

Kolbadi K. | ALIASGARI E. | BAESI K. | Issue Writer Certificate

Keywords

HIV-1Q2

discordantQ1

TCD4+ cell countQ1

Abstract

Aims: Anti-Retroviral Therapy (ART) should considerably ameliorate the recovery of the immune system in HIV infected patients. In some patients, a failure to satisfactorily increase CD4 counts on ART despite successful virological control did occur, named discordant immune response (DIR). The aim of this study is the evaluation of CD28, CXCL12, FOS genes in patients with DIR. Materials & Methods: In the current study, after PBMC isolation, RNA was extracted for two groups; Control group (immunologic responders) and case group (non-immunologic responders). Real-time relative quantitative PCR was performed in duplicate using One Step PrimeScript™ RT-PCR Kit and data analyzed by using GraphPad Prism software version 8. 0. 2. Findings: The expression levels in the case group compared to the control group were measured for CD28, CXCL12, FOS. The fold change ratio for CD28 and CXCL12 were (0. 46), (0. 19) respectively and in both of them, a significant decrease was observed. The fold change ratio for FOS was (0. 70) and no statistically significant was observed. Conclusion: we showed a significant decrease in the expression of CD28 and CXCL12 genes in the case the group compared to control group, but we couldn’ t say, this low expression of these genes are the reason for the low count of CD4 T cells. The more an investigation is necessary for it if the suppression of these genes can impact on the proliferation of CD4 T cells, in-vitro.

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References

HIV drug resistance among naï ve HIV-infected patients in Iran

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APA: Copy

Kolbadi, K., ALIASGARI, E., & BAESI, K.. (2021). Evaluation of CXCL12, CD28 and FOS gene expression in HIV-infected patients with discordance in CD4+T-Cell Levels. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(5 ), 57-63. SID. https://sid.ir/paper/412030/en

Vancouver: Copy

Kolbadi K., ALIASGARI E., BAESI K.. Evaluation of CXCL12, CD28 and FOS gene expression in HIV-infected patients with discordance in CD4+T-Cell Levels. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;23(5 ):57-63. Available from: https://sid.ir/paper/412030/en

IEEE: Copy

K. Kolbadi, E. ALIASGARI, and K. BAESI, “Evaluation of CXCL12, CD28 and FOS gene expression in HIV-infected patients with discordance in CD4+T-Cell Levels,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 5 , pp. 57–63, 2021, [Online]. Available: https://sid.ir/paper/412030/en

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