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Information Journal Paper

Title

Evaluation of Cytotoxicity Activity of Salmonella Typhimurium Protein Fractions on Melanoma B16 Cancer Cell Line

Pages

  65-74

Abstract

 Background and target: Salmonella typhimurium is a gram-negative rod-forming bacterium belonging to the family Enterobacteriaceae and Is one of the most common foodborne pathogens, that With several pathogenic factors, including toxins, Secretory proteins, and secretory system T3SS(That Causes fluid secretion And inflammation), Etc It can a suitable candidate for this stud. The purpose of this study, Evaluation of the cytotoxicity effect of bacterial protein fractions on growth and proliferation of melanoma cancer cells, which is the most resistant type of skin cancer. materials and methods: In this experimental study, the cancer cell line (B16) melanoma was used. Different bacterial fractions were prepared by the ammoniumsulfatemethod. Interaction of cancer cells with different concentrations of Salmonella typhimurium fractions was studied. Cell proliferation was assessed by MTT assay at 24 and 48 hours. findings: MTT test results with fractions (Bacteria lysate in culture medium, 80% deposition of lysate proteins, 30% deposition of lysate proteins, 80% deposition on culture Media, and 30% deposition on culture Media) The highest effect was observed at concentrations of 9. 25, 30, 8, 72, 10. 75 μ g / ml, respectively. Discussion and conclusion: Results show that bacterial fractions of Salmonella typhimurium have high toxicity and lethal effect on melanoma cancer cells. These compounds can be suggested and used as an alternative or complementary to cancer therapy.

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    APA: Copy

    NAJAFI, MINOO, SOLEIMANI, NEDA, & ALIAHMADI, ATOUSA. (2021). Evaluation of Cytotoxicity Activity of Salmonella Typhimurium Protein Fractions on Melanoma B16 Cancer Cell Line. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(5 ), 65-74. SID. https://sid.ir/paper/412454/en

    Vancouver: Copy

    NAJAFI MINOO, SOLEIMANI NEDA, ALIAHMADI ATOUSA. Evaluation of Cytotoxicity Activity of Salmonella Typhimurium Protein Fractions on Melanoma B16 Cancer Cell Line. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;23(5 ):65-74. Available from: https://sid.ir/paper/412454/en

    IEEE: Copy

    MINOO NAJAFI, NEDA SOLEIMANI, and ATOUSA ALIAHMADI, “Evaluation of Cytotoxicity Activity of Salmonella Typhimurium Protein Fractions on Melanoma B16 Cancer Cell Line,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 5 , pp. 65–74, 2021, [Online]. Available: https://sid.ir/paper/412454/en

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