Synthesis and characterization of Gelatinfunctionalized Reduced Graphene Oxide for drug delivery application

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MOSTAFAVI FATEMEH SADAT; IMANI RANA

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Journal: Pathobiology Research Year:2021 | Volume:23 | Issue:5 Page(s): 75-85

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Information Journal Paper

Title

Synthesis and characterization of Gelatinfunctionalized Reduced Graphene Oxide for drug delivery application

Author(s)

MOSTAFAVI FATEMEH SADAT | IMANI RANA | Issue Writer Certificate

Keywords

GrapheneQ1

NanocarrierQ2

CancerQ1

Drug deliveryQ1

Surface modificationQ1

Abstract

Aims Using nanomaterials in Cancer therapy has shown that this kind of treatment is more efficient with fewer side effects. A considerable number of nanomaterials that can be used in Cancer therapy are introduced; among them, Graphene attracts most of the scientist's attention due to its unique features. In this study, the Graphene oxide (GO) was synthesized and reduced by gelatin for cellular delivery of an antiCancer drug, curcumin, . Materials and Methods GO was synthesized by hummer method and reduced by gelatin. Curcumine antiCancer drug was loaded on the synthesized Nanocarriers via hudrophobe-hydrophobe interaction. Findings Chemical, physical and biological assays have been done to evaluate the synthesis and Surface modification. In the next step, the drug loading efficiency was obtained by the UV-Vis spectroscopy method. Conclusion: GO is successfully synthesized, with the average size of 300nm. AFM pictures of GO before and after reduction show an increasing in thickness that proves the presence of gelatin on the surface. From the cytotoxicity assay on L292 cell line, it can be concluded that Surface modification was effective because GO showed remarkable toxicity while gelatin-rGO does not show any toxicity even at concentration of 200 μ gml-1. Also, the drug loading efficeincy is obtained at 78%. Therefore, the gelatin-rGO with excellent stability and biocompatibility can be suggested as a drug carrier applicable in biomedical studies.

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APA: Copy

MOSTAFAVI, FATEMEH SADAT, & IMANI, RANA. (2021). Synthesis and characterization of Gelatinfunctionalized Reduced Graphene Oxide for drug delivery application. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(5 ), 75-85. SID. https://sid.ir/paper/412455/en

Vancouver: Copy

MOSTAFAVI FATEMEH SADAT, IMANI RANA. Synthesis and characterization of Gelatinfunctionalized Reduced Graphene Oxide for drug delivery application. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;23(5 ):75-85. Available from: https://sid.ir/paper/412455/en

IEEE: Copy

FATEMEH SADAT MOSTAFAVI, and RANA IMANI, “Synthesis and characterization of Gelatinfunctionalized Reduced Graphene Oxide for drug delivery application,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 5 , pp. 75–85, 2021, [Online]. Available: https://sid.ir/paper/412455/en

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