Effects of L-Arginine and L-NAME on Rat Duodenum Epithelial Cell Numbers and Height

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NADIA SHARIFI ZAHRA; movasaghi shabnam; mostafavi atarodsadat; noori mogehi seyed mohammad hossein

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Journal: Journal of Medical Council of Iran Year:2021 | Volume:39 | Issue:1 Page(s): 50-54

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Title

Effects of L-Arginine and L-NAME on Rat Duodenum Epithelial Cell Numbers and Height

Author(s)

NADIA SHARIFI ZAHRA | movasaghi shabnam | mostafavi atarodsadat | noori mogehi seyed mohammad hossein | Issue Writer Certificate

Keywords

Nitric OxideQ2

L-ArginineQ2

L-NAMEQ2

Epithelial cells of DuodenumQ1

Abstract

Introduction Nowadays Nitric Oxide (NO) has known as a regulator of many biological processes in many cells including epithelial cell of gastrointestinal tract. In this study we investigated the effects of L-Arginine and L-NAME on epithelial cell number and height of duodenum in rats. Methods 40 female rats of 200-250 gr weight and 8 weeks old were divided into 5 groups, containing 8 rats in each group. Except the control group, the other groups received normal saline (2 ml/kg), L-Arginine (200mg/kg), L-NAME (20mg/kg) and L-Arginine+L-NAME with same doses Intraperitoneally for 3 days. Two weeks later, duodenum was expelled out and fixed in 10% formalin. After tissue processing, the sections were stained with H&E method. The histological changes were assessed via light microscopy. Cell number and height were evaluated using morphometric and histologic methods. Statistical analysis was made by One-Way ANOVA followed by Tukey post hoc test to evaluate the statistical significance between different groups. P value less than 0. 05 was considered statistically significant. Results There was an increase in the cell number and height of duodenal epithelium in L-NAME group; also a decrease in the cell height of duodenal epithelium in L-Arginine group. No significant difference was observed between groups (p>0. 05). Conclusion Despite the importance of NO in many cells function, the results demonstrated that L-Arginine and L-NAME has no effect on number and height of duodenal epithelium.

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APA: Copy

NADIA SHARIFI, ZAHRA, movasaghi, shabnam, mostafavi, atarodsadat, & noori mogehi, seyed mohammad hossein. (2021). Effects of L-Arginine and L-NAME on Rat Duodenum Epithelial Cell Numbers and Height. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 39(1 ), 50-54. SID. https://sid.ir/paper/412536/en

Vancouver: Copy

NADIA SHARIFI ZAHRA, movasaghi shabnam, mostafavi atarodsadat, noori mogehi seyed mohammad hossein. Effects of L-Arginine and L-NAME on Rat Duodenum Epithelial Cell Numbers and Height. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2021;39(1 ):50-54. Available from: https://sid.ir/paper/412536/en

IEEE: Copy

ZAHRA NADIA SHARIFI, shabnam movasaghi, atarodsadat mostafavi, and seyed mohammad hossein noori mogehi, “Effects of L-Arginine and L-NAME on Rat Duodenum Epithelial Cell Numbers and Height,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 39, no. 1 , pp. 50–54, 2021, [Online]. Available: https://sid.ir/paper/412536/en

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