EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES

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Shekari Esmail; HOSSEINI SEYED KIANOOSH; RAZI FARIDEH; NASLI ESFAHANI ENSIEH; QORBANI MOSTAFA; LARIJANI BAGHER

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Journal: Iranian Journal of Diabetes and Metabolism Year:2020 | Volume:19 | Issue:4 Page(s): 205-216

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Title

EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES

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Keywords

MetabolomicsQ1

Amino AcidQ2

Cardiovascular DiseaseQ1

Type 2 DiabetesQ1

Abstract

Background: Diabetes mellitus is one of the most common endocrine diseases. Cardiovascular Disease (CVD) is one of the leading causes of death in patients with Type 2 Diabetes. The aim of this study was to investigate the metabolic profile of plasma Amino Acids in diabetic patients with Cardiovascular Disease. Methods: The present study is a descriptive-analytical cross-sectional study on 140 patients including 35 patients with Type 2 Diabetes and Cardiovascular Disease (CVD. DM), 35 patients with Type 2 Diabetes and non-Cardiovascular Disease (DM). 35 non-diabetic patients with Cardiovascular Disease (CVD. nDM) and 35 non-diabetic patients with non-Cardiovascular Disease (HS) were referred to Diabetes Clinic No. 1 of Tehran University of Medical Sciences. Results: 76 (54. 3%) were male and 64 (45. 7%) were female. The highest concentrations of glutamine and isoleucine were observed in DM. CVD, asparagine, serine, arginine, threonine, alanine, tyrosine, valine in DM. nCVD and methionine in CVD. nDM. The lowest concentrations of tyrosine and tryptophan in DM. CVD has been detected, and methionine has been detected in DM. nCVD. The Amino Acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine significantly increased the chances of developing DM. nCVD. For each increase in Z-score per plasma concentration of isoleucine, the chances of developing Cardiovascular Disease without diabetes were significantly increased. Conclusion: The Amino Acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine are involved in predicting the risk of DM. nCVD and isoleucine and methionine are involved in predicting the risk of CVD. nDM.

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APA: Copy

Shekari, Esmail, HOSSEINI, SEYED KIANOOSH, RAZI, FARIDEH, NASLI ESFAHANI, ENSIEH, QORBANI, MOSTAFA, & LARIJANI, BAGHER. (2020). EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(4 ), 205-216. SID. https://sid.ir/paper/412574/en

Vancouver: Copy

Shekari Esmail, HOSSEINI SEYED KIANOOSH, RAZI FARIDEH, NASLI ESFAHANI ENSIEH, QORBANI MOSTAFA, LARIJANI BAGHER. EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(4 ):205-216. Available from: https://sid.ir/paper/412574/en

IEEE: Copy

Esmail Shekari, SEYED KIANOOSH HOSSEINI, FARIDEH RAZI, ENSIEH NASLI ESFAHANI, MOSTAFA QORBANI, and BAGHER LARIJANI, “EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 4 , pp. 205–216, 2020, [Online]. Available: https://sid.ir/paper/412574/en

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