THE EFFECT OF ENDURANCE TRAINING ON THE CONTENT MYOSTATIN AND SMAD2/3 PROTEINS IN THE LEFT VENTRICULAR TISSUE OF THE HEART MUSCLE OF TYPE 1 DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JOKAR MASOUD; Amirahmadi Mousa; SHERAFATI MOGHADAM MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2021 | Volume:20 | Issue:3 Page(s): 191-199

Download Full-Text

Persian Verion

View:

290

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ENDURANCE TRAINING ON THE CONTENT MYOSTATIN AND SMAD2/3 PROTEINS IN THE LEFT VENTRICULAR TISSUE OF THE HEART MUSCLE OF TYPE 1 DIABETIC RATS

Author(s)

JOKAR MASOUD | Amirahmadi Mousa | SHERAFATI MOGHADAM MOHAMMAD | Issue Writer Certificate

Keywords

Endurance TrainingQ1

Cardiac MuscleQ1

Myostatin ProteinQ1

SMAD2/3 ProteinQ1

Type 1 DiabetesQ1

Abstract

Background: The myostatin/SMAD pathway is one of the most important regulatory pathways in heart muscle cells atrophy. Diabetes can disorder this pathway. Therefore, the aim of the present study was to evaluate the effect of six weeks of Endurance Training on the content myostatin and SMAD2/3 Proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats. Methods: In this study, 12 head 2-month-old male Sprague-Dawley male rats with a mean weight of 300± 20 g were selected. After induction of diabetes through streptozotocin solution, they were randomly divided into 2 groups: diabetic Endurance Training (6 heads) and diabetic control (6 heads); The training groups performed the training program 4 days a week for 6 weeks, including 32 minutes of Endurance Training with an intensity of about 50 to 70% of the maximum speed; SPSS software version 23 and independent t-test were used to analyze the data. Significance level was considered p≤ 0. 05. Findings: Endurance Training resulted in a significant decrease in myostatin (P=0. 024) and SMAD2/3 (P=0. 001) proteins content between training and control groups in myocardial tissue. Conclusion: It can be said that Endurance Training by reducing the content of myostatin and SMAD2/3 Proteins in the left ventricle of the heart may have been able to prevent cardiac atrophy in type 1 diabetic subjects. This reduction can lead to physiological cardiac hypertrophy.

Cites

The Effect of Long-Term High-Intensity Interval Training on the Intracellular Content of Mafbx and Murf1 Proteins in the Left Ventricular of the Heart of Rats With Type 2 Diabetes

References

Cite

APA: Copy

JOKAR, MASOUD, Amirahmadi, Mousa, & SHERAFATI MOGHADAM, MOHAMMAD. (2021). THE EFFECT OF ENDURANCE TRAINING ON THE CONTENT MYOSTATIN AND SMAD2/3 PROTEINS IN THE LEFT VENTRICULAR TISSUE OF THE HEART MUSCLE OF TYPE 1 DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 20(3 ), 191-199. SID. https://sid.ir/paper/412618/en

Vancouver: Copy

JOKAR MASOUD, Amirahmadi Mousa, SHERAFATI MOGHADAM MOHAMMAD. THE EFFECT OF ENDURANCE TRAINING ON THE CONTENT MYOSTATIN AND SMAD2/3 PROTEINS IN THE LEFT VENTRICULAR TISSUE OF THE HEART MUSCLE OF TYPE 1 DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;20(3 ):191-199. Available from: https://sid.ir/paper/412618/en

IEEE: Copy

MASOUD JOKAR, Mousa Amirahmadi, and MOHAMMAD SHERAFATI MOGHADAM, “THE EFFECT OF ENDURANCE TRAINING ON THE CONTENT MYOSTATIN AND SMAD2/3 PROTEINS IN THE LEFT VENTRICULAR TISSUE OF THE HEART MUSCLE OF TYPE 1 DIABETIC RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 20, no. 3 , pp. 191–199, 2021, [Online]. Available: https://sid.ir/paper/412618/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops