The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF21 and VEGF Gene Expression in Patients With Coronary Artery Diseases

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Roohbakhsh Ebad; BARARI ALIREZA; Abbaszadeh Hajar

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Journal: Internal Medicine Today Year:2021 | Volume:27 | Issue:2 Page(s): 130-146

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Information Journal Paper

Title

The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF21 and VEGF Gene Expression in Patients With Coronary Artery Diseases

Author(s)

Roohbakhsh Ebad | BARARI ALIREZA | Abbaszadeh Hajar | Issue Writer Certificate

Keywords

Interval trainingQ1

FenugreekQ2

Fibroblast Growth Factor (FGF21)Q1

Vascular Endothelial Growth Factor (VEGF)Q1

Coronary artery diseaseQ3

Abstract

Aims: A high-fat diet, smoking, and a sedentary lifestyle are the major causes of Coronary artery disease (CAD). This study aimed to explore the effect of Interval training and the consumption of Fenugreek seed extract on FGF-21 and VEGF gene expression among patients with CAD. Methods & Materials: The present quasi-experimental study was conducted on a sample of 32 male patients with CAD, aged between 55 and 65 years. They were randomly divided into four groups: control, training only, Fenugreek only, and training + Fenugreek. The training program consisted of eight weeks of interval running, three sessions per week with an intensity of 55% and 65% of heart rate reserve, with a gradually increasing intensity. Subjects consumed 10 mg/kg of Fenugreek extract daily. Real-time PCR was used to measure the expression of FGF-21 and VEGF genes. Findings: The results showed that the mean expression ratios of FGF-21 in training only, Fenugreek only, and training + Fenugreek groups were significantly higher than the control group (P<0. 0001). The Fenugreek + training group had a greater significant increase (P<0. 0001) more than the training + Fenugreek group. Moreover, the mean Coefficient of Variation (CV) of VEGF gene expression was significantly increased more than that in the training group (P<0. 0001), Fenugreek group (P=0. 0004), and the training + Fenugreek group (P<0. 0001), compared to the control group. The Fenugreek + training group had a greater and more significant increase than the training only (P=0. 0181) and the Fenugreek only groups (P<0. 0495). Conclusion: The results showed that a combination of Interval training and consumption of Fenugreek seed extract increased the CV of FGF-21 and VEGF gene expression and thus, have beneficial effects on the angiogenesis pathway in patients with CADs.

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APA: Copy

Roohbakhsh, Ebad, BARARI, ALIREZA, & Abbaszadeh, Hajar. (2021). The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF21 and VEGF Gene Expression in Patients With Coronary Artery Diseases. OFOGH-E-DANESH, 27(2 ), 130-146. SID. https://sid.ir/paper/412893/en

Vancouver: Copy

Roohbakhsh Ebad, BARARI ALIREZA, Abbaszadeh Hajar. The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF21 and VEGF Gene Expression in Patients With Coronary Artery Diseases. OFOGH-E-DANESH[Internet]. 2021;27(2 ):130-146. Available from: https://sid.ir/paper/412893/en

IEEE: Copy

Ebad Roohbakhsh, ALIREZA BARARI, and Hajar Abbaszadeh, “The Effect of Interval Training and Consuming Fenugreek Seed Extract on FGF21 and VEGF Gene Expression in Patients With Coronary Artery Diseases,” OFOGH-E-DANESH, vol. 27, no. 2 , pp. 130–146, 2021, [Online]. Available: https://sid.ir/paper/412893/en

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