BIOINFORMATIC STUDY ON EFFECT OF XANTHOHUMOL AS BIOACTIVE COMPOUND OF HOP IN THE INHIBITION OF THE MAPK/ERK PATHWAY IN THYROID CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Gholizadeh Siahmazgi Zohreh; IRANI SHIVA; GHIASEDDIN ALI; Fallah Parviz; HAGHPANAH VAHID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2020 | Volume:19 | Issue:4 Page(s): 225-233

Download Full-Text

Persian Verion

View:

345

Download:

Cites:

Information Journal Paper

Title

BIOINFORMATIC STUDY ON EFFECT OF XANTHOHUMOL AS BIOACTIVE COMPOUND OF HOP IN THE INHIBITION OF THE MAPK/ERK PATHWAY IN THYROID CANCER

Author(s)

Keywords

PharmacokineticQ3

PharmacodynamicQ1

XanthohumolQ1

MAPK/ERK pathwayQ1

Abstract

Background: Xanthohumol is one of the main bioactive compounds extracted from the female flowers of the hops plant (Humulus lupulus L), that has been shown in several studies to have anti-cancer effects. The MAPK/ERK pathway is one of the key pathways in the regulation of gene expression, cell growth and survival. The abnormal activation of this pathway leads to the uncontrolled cell proliferation in thyroid cancer. This study aims to perform a bioinformatic screening of the proteins in the MAPK/ERK pathway and introduce them as target protein to Xanthohumol. In addition, due to the significant role of EGFR, Grb2, SOS proteins in the MAPK/ERK pathway, they have also been studied. Method: Using SwissADME software, first the physicochemical, Pharmacokinetic and Pharmacodynamic characteristics of Xanthohumol are predicted. Then three-dimensional structure of Xanthohumol and target proteins (EGFR, Grb2, SOS, RAS, BRAF, MEK1, MEK2, ERK1, ERK2) were collected from PubChem database and Protein Data Bank, finally, using Auto Dock 4. 1. the molecular docking were studied. Results: Our study shows lack of cytotoxicity in Xanthohumol. In addition, Xanthohumol with proper physicochemical properties does not induce drug resistance through pump P-glycoprotein mechanism. Analysis of molecular docking indicate that Xanthohumol has inhibitory potential to the all proteins studied. Note that its strongest interaction is with MEK2 protein with binding energy-7. 04kcal. mol. Conclusion: According to our results, Xanthohumol has inhibitory potential to the all proteins present in the MAPK/ERK pathway. It lacks cytotoxicity. Thus, it can be considered as an alternative inhibitor for the MAPK/ERK pathway in thyroid cancer cells.

Cites

No record.

References

Cite

APA: Copy

Gholizadeh Siahmazgi, Zohreh, IRANI, SHIVA, GHIASEDDIN, ALI, Fallah, Parviz, & HAGHPANAH, VAHID. (2020). BIOINFORMATIC STUDY ON EFFECT OF XANTHOHUMOL AS BIOACTIVE COMPOUND OF HOP IN THE INHIBITION OF THE MAPK/ERK PATHWAY IN THYROID CANCER. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(4 ), 225-233. SID. https://sid.ir/paper/413110/en

Vancouver: Copy

Gholizadeh Siahmazgi Zohreh, IRANI SHIVA, GHIASEDDIN ALI, Fallah Parviz, HAGHPANAH VAHID. BIOINFORMATIC STUDY ON EFFECT OF XANTHOHUMOL AS BIOACTIVE COMPOUND OF HOP IN THE INHIBITION OF THE MAPK/ERK PATHWAY IN THYROID CANCER. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(4 ):225-233. Available from: https://sid.ir/paper/413110/en

IEEE: Copy

Zohreh Gholizadeh Siahmazgi, SHIVA IRANI, ALI GHIASEDDIN, Parviz Fallah, and VAHID HAGHPANAH, “BIOINFORMATIC STUDY ON EFFECT OF XANTHOHUMOL AS BIOACTIVE COMPOUND OF HOP IN THE INHIBITION OF THE MAPK/ERK PATHWAY IN THYROID CANCER,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 4 , pp. 225–233, 2020, [Online]. Available: https://sid.ir/paper/413110/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops