THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS

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Angouti Mahdi; RAJABI HAMID; Gharakhanloo Reza; Dehkhoda Mohammad Reza

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Journal: Iranian Journal of Diabetes and Metabolism Year:2021 | Volume:20 | Issue:2 Page(s): 83-92

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Title

THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS

Author(s)

Angouti Mahdi | RAJABI HAMID | Gharakhanloo Reza | Dehkhoda Mohammad Reza | Issue Writer Certificate

Keywords

Aerobic ExerciseQ2

L-CarnitineQ1

CNTFQ1

CNTFRQ1

DiabetesQ2

HypocampusQ3

Abstract

Background: Diabetes causes nerve tissue damage and ultimately death of nerve cells, especially in important areas such as the hippocampus. It seems that exercise training and anti-inflammatory supplements can moderate this condition. Therefore, the aim of this study was to determine the effect of aerobic training exercise and L-Carnitine consumption on the levels of hippocampus CNTF and CNTFR proteins in diabetic rat. Methods: 45 Wistar rats between 250 to 300 gr were randomly divided into six groups, including healthy control groups, sham, diabetic control, Diabetes + Aerobic Exercise, Diabetes + L-Carnitine supplementation and Diabetes + Aerobic Exercise + L-Carnitine supplementation. L-Carnitine supplements were divided. Diabetic groups underwent subcutaneous injection of 55 mg / kg STZ. supplementary groups received 100 mg of L-Carnitine per day orally. The Aerobic Exercise program was performed for 6 weeks and 5 days a week. The research variables were measured 24 hours after the last training session by the ELISA technics in the hippocampal tissue. The statistical method of one-way analysis of variance and Toki post – hoc test were used to analyze the data. Results: The present study showed an significant increase in CNTF and CNTFR protein levels of hippocampal tissue after Aerobic Exercise and L-Carnitine consumption (P = 0. 001), which greater effect found in combination manner. Conclusion: Due to the effect of Aerobic Exercise and L-Carnitine supplementation alone and in interaction with each other on hippocampal tissue, the use of this method can be considered as maintaining neural tissue in Diabetes.

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APA: Copy

Angouti, Mahdi, RAJABI, HAMID, Gharakhanloo, Reza, & Dehkhoda, Mohammad Reza. (2021). THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 20(2 ), 83-92. SID. https://sid.ir/paper/413148/en

Vancouver: Copy

Angouti Mahdi, RAJABI HAMID, Gharakhanloo Reza, Dehkhoda Mohammad Reza. THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;20(2 ):83-92. Available from: https://sid.ir/paper/413148/en

IEEE: Copy

Mahdi Angouti, HAMID RAJABI, Reza Gharakhanloo, and Mohammad Reza Dehkhoda, “THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 20, no. 2 , pp. 83–92, 2021, [Online]. Available: https://sid.ir/paper/413148/en

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