INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK

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Fakhraei Nasab Anahita; Aghaei Meybodi Hamid Reza; AFSHARI MAHDI; Sarhangi Negar; HASANZAD MANDANA

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Journal: Iranian Journal of Diabetes and Metabolism Year:2020 | Volume:19 | Issue:4 Page(s): 217-224

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Title

INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK

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Keywords

MelatoninQ2

MTNR1BQ1

rs4753426Q1

T2DMQ1

Abstract

Background: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of MTNR1B gene are reported to be associated with T2DM susceptibility. We investigated the association between rs4753426 variant in the MTNR1B gene and the risk of T2DM in group of Iranian patients. Methods: In this case-control study108 T2DM and 100 normal individuals were recruited to genotyping by PCR-RFLP. Results: It was observed a significant difference in CC, CT, and TT genotypes distribution between T2DM and control groups (P<0. 001). Frequency of C allele among cases was significantly lower than controls (8. 3% vs. 42. 5% respectively, P<0. 001) and C allele carriers had a 88% lower risk of developing T2DM than T carriers. Conclusion: Our results showed that the rs4753426 variant of MTNR1B gene could reduce the risk of T2DM developing.

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APA: Copy

Fakhraei Nasab, Anahita, Aghaei Meybodi, Hamid Reza, AFSHARI, MAHDI, Sarhangi, Negar, & HASANZAD, MANDANA. (2020). INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(4 ), 217-224. SID. https://sid.ir/paper/413541/en

Vancouver: Copy

Fakhraei Nasab Anahita, Aghaei Meybodi Hamid Reza, AFSHARI MAHDI, Sarhangi Negar, HASANZAD MANDANA. INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(4 ):217-224. Available from: https://sid.ir/paper/413541/en

IEEE: Copy

Anahita Fakhraei Nasab, Hamid Reza Aghaei Meybodi, MAHDI AFSHARI, Negar Sarhangi, and MANDANA HASANZAD, “INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 4 , pp. 217–224, 2020, [Online]. Available: https://sid.ir/paper/413541/en

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