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Information Journal Paper

Title

The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats

Pages

  361-371

Abstract

 Background & Objectives: Based on the probably positive role of exercise on total oxidative status (TOS ) and total antioxidant system (TAS ) and their effect on the process of Angiogenesis, the aim of the current study was to evaluate the effect of one course of moderate-intensity endurance training on the gene expression level of vascular endothelial growth factor-B (VEGF-B ) and angiopoietin-1(ANGPT-1) and TAS and TOS status in cardiac tissue of male rats. Methods: In this study, 20 male Wistar rats were divided into two equal groups as follows: 1-training group and 2-control group: no sports activities were performed on them. Rats in the training group performed moderate endurance training for 6 weeks and 5 sessions per week from the twelfth week of life. Twenty-four hours after the last training session, Heart tissue samples were extracted to measure gene expression levels of VEGF-B and ANGPT-1 and the TAS and TOS status in Heart tissues. T-test with the statistical level of (p˂ 0. 05) was used for between groups comparison. Results: Findings showed that after six weeks of endurance training, the expression level of ANGPT-1 and VEGF-B and the amount of TAS in the exercise group significantly increased (p=0. 001) and the amount of TOS significantly decreased compared to the control group (p=0. 008). Conclusion: According to the results of the present study, it seems that moderate-intensity endurance training can be effective in preventing cardiovascular disease by increasing factors involving in Angiogenesis, improving TAS and reducing TOS in Heart tissue of rats.

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    Cite

    APA: Copy

    SEIFI SKISHAHR, F., & Khajehlandi, M.. (2020). The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 20(3 ), 361-371. SID. https://sid.ir/paper/413766/en

    Vancouver: Copy

    SEIFI SKISHAHR F., Khajehlandi M.. The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2020;20(3 ):361-371. Available from: https://sid.ir/paper/413766/en

    IEEE: Copy

    F. SEIFI SKISHAHR, and M. Khajehlandi, “The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 20, no. 3 , pp. 361–371, 2020, [Online]. Available: https://sid.ir/paper/413766/en

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