ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK

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Bozorgnejad Negin; Aghaei Meybodi Hamid Reza; AFSHARI MAHDI; Sarhangi Negar; HASANZAD MANDANA

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Journal: Iranian Journal of Diabetes and Metabolism Year:2020 | Volume:19 | Issue:3 Page(s): 114-122

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Title

ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK

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Keywords

Type 2 diabetesQ1

MTNR1B geneQ1

rs10830962Q1

Abstract

Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin secretion in β-cells. The aim of this study was to examine the association between MTNR1B (rs10830962) gene polymorphism and the risk of T2DM. Methods: Genotyping was carried out in a total number of 208 subjects including 108 patients with T2DM and 100 normal controls using polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) which is confirmed by Sanger sequencing method. Results: The frequencies of CC, GC and GG among cases were 54. 63%, 1. 85% and 43. 52% and in control subjects were 81%, 0% and 19% respectively (P<0. 001). Frequency of G allele among diabetic patients was significantly higher than non-diabetics (OR=3. 34, CI=2. 10-5. 36, P<0. 001). Conclusion: Our study showed that rs10830962 polymorphism of the MTNR1B gene can be directly associated with T2DM risk.

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APA: Copy

Bozorgnejad, Negin, Aghaei Meybodi, Hamid Reza, AFSHARI, MAHDI, Sarhangi, Negar, & HASANZAD, MANDANA. (2020). ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(3 ), 114-122. SID. https://sid.ir/paper/413815/en

Vancouver: Copy

Bozorgnejad Negin, Aghaei Meybodi Hamid Reza, AFSHARI MAHDI, Sarhangi Negar, HASANZAD MANDANA. ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(3 ):114-122. Available from: https://sid.ir/paper/413815/en

IEEE: Copy

Negin Bozorgnejad, Hamid Reza Aghaei Meybodi, MAHDI AFSHARI, Negar Sarhangi, and MANDANA HASANZAD, “ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 3 , pp. 114–122, 2020, [Online]. Available: https://sid.ir/paper/413815/en

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