A Comprehensive Review on Medication Used for Warfarin Reversal

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GHAFARI SOMAYEH; HAJHOSEINTALASAZ AZITA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medical Council of Iran Year:2018 | Volume:36 | Issue:2 Page(s): 67-73

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Information Journal Paper

Title

A Comprehensive Review on Medication Used for Warfarin Reversal

Author(s)

GHAFARI SOMAYEH | HAJHOSEINTALASAZ AZITA | Issue Writer Certificate

Keywords

WarfarinQ2

Warfarin reversalQ1

Vitamin KQ1

FFPQ1

PCCQ1

rFVIIaQ1

Abstract

Warfarin sodium as an anticoagulant, is widely used for the prevention and treatment of venous and arterial thrombosis. As a Vitamin K antagonist, Warfarin effectively decreases the hepatic production of clotting factors II, VII, IX, and X, along with proteins C and S. While anticoagulants such as Warfarin have well-established indications, they are also associated with few side effects such as haemorrhage. Many patients receiving Vitamin K antagonists have an International Normalized Ratio (INR) higher than the target of 2. 0 to 3. 0 for over 50% of the time, which is followed with increasing risk of bleeding. In this situation the clinical need for emergency reversal of anticoagulation is necessary. There are a number of potential treatment options for anticoagulant reversal, including administration of Vitamin K (oral or intravenous), human plasma products [for example, Fresh Frozen Plasma (FFP)], prothrombin complex concentrates (PCCs); concentrates that contain coagu-lation factors II, VII, IX and X), or single coagulation factors such as activated re-combinant factor VII (rFVIIa). The aim of this paper was to conduct a review of the medical literature and summarize the advantages and risks of the available treatment options for reversing Warfarin anticoagulation in patients receiving Warfarin.

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APA: Copy

GHAFARI, SOMAYEH, & HAJHOSEINTALASAZ, AZITA. (2018). A Comprehensive Review on Medication Used for Warfarin Reversal. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 36(2 ), 67-73. SID. https://sid.ir/paper/41383/en

Vancouver: Copy

GHAFARI SOMAYEH, HAJHOSEINTALASAZ AZITA. A Comprehensive Review on Medication Used for Warfarin Reversal. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2018;36(2 ):67-73. Available from: https://sid.ir/paper/41383/en

IEEE: Copy

SOMAYEH GHAFARI, and AZITA HAJHOSEINTALASAZ, “A Comprehensive Review on Medication Used for Warfarin Reversal,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 36, no. 2 , pp. 67–73, 2018, [Online]. Available: https://sid.ir/paper/41383/en

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