Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand (Short Communication)

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Abasnia Fatemeh; FAKHARIAN TAHEREH; Salmany Fatemeh

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Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2021 | Volume:28 | Issue:2 Page(s): 179-184

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Information Journal Paper

Title

Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand (Short Communication)

Author(s)

Abasnia Fatemeh | FAKHARIAN TAHEREH | Salmany Fatemeh | Issue Writer Certificate

Keywords

ClarithromycinQ2

EradicationQ2

Helicobacter pylori infectionQ2

LevofloxacinQ1

Abstract

Since helicobacter pylori is a prevalent infection in Iran, it is necessary to search for an effective, low-cost, and easy diet to eradicate it. This study compares the effect of Levofloxacin-based regimen along with Clarithromycin-based regimen on the treatment of helicobacter pylori (H. pylori). This quasi-experimental study was performed on 161 patients with H. pylori infection who referred to the gastrointestinal clinic of Valiasr Hospital in Birjand, Iran. The patients were randomly divided into two groups. The first group was treated with Levofloxacin, pantoprazole, and amoxicillin, and the second group received amoxicillin, pantoprazole, Clarithromycin, and bismuth sub citrate for 14 days. The urease breath test was performed four weeks after the end of the treatment to check the Eradication of the condition. The Eradication occurred in 67 (91. 8%) and 55 (70. 5%) patients treated with Levofloxacin and Clarithromycin, respectively. A p-value of 0. 001 was considered statistically significant. Moreover, there was no statistically significant difference between two groups in terms of complications (P=0. 3). The results showed that the Levofloxacin-based regimen could be used as an alternative to four Clarithromycin-based therapies due to its greater efficacy in Eradication of H. pylori despite the lower number of drugs and similar side effects.

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References

High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: A randomized trial

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APA: Copy

Abasnia, Fatemeh, FAKHARIAN, TAHEREH, & Salmany, Fatemeh. (2021). Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand (Short Communication). JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 28(2 ), 179-184. SID. https://sid.ir/paper/413931/en

Vancouver: Copy

Abasnia Fatemeh, FAKHARIAN TAHEREH, Salmany Fatemeh. Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand (Short Communication). JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(2 ):179-184. Available from: https://sid.ir/paper/413931/en

IEEE: Copy

Fatemeh Abasnia, TAHEREH FAKHARIAN, and Fatemeh Salmany, “Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand (Short Communication),” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 2 , pp. 179–184, 2021, [Online]. Available: https://sid.ir/paper/413931/en

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