COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS

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SHAHIDI FERESHTEH; Yazdani Faramarz; GAEINI ABBASALI; KARIMI POURAN

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Journal: Iranian Journal of Diabetes and Metabolism Year:2019 | Volume:18 | Issue:5 Page(s): 236-245

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Title

COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS

Author(s)

SHAHIDI FERESHTEH | Yazdani Faramarz | GAEINI ABBASALI | KARIMI POURAN | Issue Writer Certificate

Keywords

AngiogenesisQ2

DiabetesQ2

Heart MuscleQ1

Continuous Moderate ExerciseQ1

Interval Severe ExercisesQ1

Abstract

Background: Diabetic cardiomyopathy is the first cause of death in diabetic patients and Angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart Angiogenesis in Wistar male diabetic rats. Methods: 32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ 1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000). Results: The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ 1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0. 05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase. Conclusion: Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of Diabetes.

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APA: Copy

SHAHIDI, FERESHTEH, Yazdani, Faramarz, GAEINI, ABBASALI, & KARIMI, POURAN. (2019). COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 18(5 ), 236-245. SID. https://sid.ir/paper/414042/en

Vancouver: Copy

SHAHIDI FERESHTEH, Yazdani Faramarz, GAEINI ABBASALI, KARIMI POURAN. COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2019;18(5 ):236-245. Available from: https://sid.ir/paper/414042/en

IEEE: Copy

FERESHTEH SHAHIDI, Faramarz Yazdani, ABBASALI GAEINI, and POURAN KARIMI, “COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 18, no. 5 , pp. 236–245, 2019, [Online]. Available: https://sid.ir/paper/414042/en

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