The importance of mesenchymal stem cells in skin wound healing

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FAKHR TAHA MASOUMEH; JAVERI ARASH

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Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2021 | Volume:28 | Issue:2 Page(s): 259-273

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Information Journal Paper

Title

The importance of mesenchymal stem cells in skin wound healing

Author(s)

FAKHR TAHA MASOUMEH | JAVERI ARASH | Issue Writer Certificate

Keywords

Mesenchymal stem cellsQ2

ParacrineQ1

ImmunomodulationQ1

HealingQ3

Skin woundQ2

Abstract

Introduction: Mesenchymal stem cells (MSCs) have been identified as an attractive source for cell therapy of damaged tissues. The multipotential differentiation capability, easy accessibility, low immunogenicity and significant role in wound Healing physiology have led to the widespread use of these cells for wound Healing. In this review study, the role of Mesenchymal stem cells in repair of Skin wounds is discussed. Materials and Methods: This review was written based on findings from a search of the PubMed and Google Scholar databases between 1990 and 2020. Results: Mesenchymal stem cells have important roles at all stages of wound Healing. These cells migrate to the site of skin damage and not only differentiate into the skin cells but also through Paracrine signalling inhibit the immune and inflammatory responses, induce proliferation and differentiation of resident progenitor cells and result in angiogenesis, epithelialization and granule tissue formation. In the regeneration and maturation phase, the MSCs reduce scar formation and wound contraction and increase collagen expression and wound tensile strength. These cells alter their function based on the biomolecular properties of the lesion site, and create a wound-Healing rather than fibrotic microenvironment. Conclusion: Todays, significant advances have been made in the delivery of MSCs into Healing wounds. These cells are delivered via intravenous or intradermal injection, or delivered with scaffolds, as a fibrin polymer spray or with hydrogels. In addition, the extracellular vesicles and conditioned medium of MSCs alone are effective. Future studies could lead to more effective strategies for the use of Mesenchymal stem cells in wound Healing.

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APA: Copy

FAKHR TAHA, MASOUMEH, & JAVERI, ARASH. (2021). The importance of mesenchymal stem cells in skin wound healing. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 28(2 ), 259-273. SID. https://sid.ir/paper/414194/en

Vancouver: Copy

FAKHR TAHA MASOUMEH, JAVERI ARASH. The importance of mesenchymal stem cells in skin wound healing. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(2 ):259-273. Available from: https://sid.ir/paper/414194/en

IEEE: Copy

MASOUMEH FAKHR TAHA, and ARASH JAVERI, “The importance of mesenchymal stem cells in skin wound healing,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 2 , pp. 259–273, 2021, [Online]. Available: https://sid.ir/paper/414194/en

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