Ethical Issues in Genome Editing and Gene Therapy with Emphasizing on CRISPR-Cas System

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YAGHOOBI HAJAR; Safaei Mohsen; SHOJAEIAN ALI; Sanami Samira

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Journal Paper

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Journal: Iranian Journal of Medical Ethics and History of Medicine Year:2019 | Volume:12 | Issue:1 Page(s): 349-360

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Information Journal Paper

Title

Ethical Issues in Genome Editing and Gene Therapy with Emphasizing on CRISPR-Cas System

Author(s)

YAGHOOBI HAJAR | Safaei Mohsen | SHOJAEIAN ALI | Sanami Samira | Issue Writer Certificate

Keywords

EthicsQ2

Gene therapyQ1

Gene EditingQ1

CRISPR-CasQ1

Abstract

Gene therapy entails the introduction of specific, functional genes into cells for therapeutic or preventive purposes. This process may be used in vitro or directly in vivo. One of the novel methods of Gene therapy and genome editing that has been introduced in recent years and have made great changes in the field of genetic engineering and biotechnology is CRISPR-Cas gene-editing system. This system is faster, cheaper, more accurate and efficient than another genome editing one, such as TALEN and ZFNs. As with any other emerging process, the ethical concerns and challenges associated with the genome editing methods including the potential application of this technique for nefarious purposes, such as, bioterrorism, harmful mutations to the living being, and disrupting ecological balance. This review was prepared using the databases of Science Direct, Pub-Med, SID, Scopus, Web of Science, and then, the selected papers were fully reviewed and information was extracted and summarized. According to the ethical and legal considerations surrounding the processes in Gene therapy, it is expected that appropriate conditions will be provided to make the best use of Gene therapy and to reduce concerns and possible abuses. The purpose of this review was to investigate ethical issues of the genome editing and Gene therapy with an emphasis on the CRISPR-Cas system.

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APA: Copy

YAGHOOBI, HAJAR, Safaei, Mohsen, SHOJAEIAN, ALI, & Sanami, Samira. (2019). Ethical Issues in Genome Editing and Gene Therapy with Emphasizing on CRISPR-Cas System. JOURNAL OF MEDICAL ETHICS AND HISTORY OF MEDICINE, 12(1 ), 349-360. SID. https://sid.ir/paper/414337/en

Vancouver: Copy

YAGHOOBI HAJAR, Safaei Mohsen, SHOJAEIAN ALI, Sanami Samira. Ethical Issues in Genome Editing and Gene Therapy with Emphasizing on CRISPR-Cas System. JOURNAL OF MEDICAL ETHICS AND HISTORY OF MEDICINE[Internet]. 2019;12(1 ):349-360. Available from: https://sid.ir/paper/414337/en

IEEE: Copy

HAJAR YAGHOOBI, Mohsen Safaei, ALI SHOJAEIAN, and Samira Sanami, “Ethical Issues in Genome Editing and Gene Therapy with Emphasizing on CRISPR-Cas System,” JOURNAL OF MEDICAL ETHICS AND HISTORY OF MEDICINE, vol. 12, no. 1 , pp. 349–360, 2019, [Online]. Available: https://sid.ir/paper/414337/en

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