The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity

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Khajeh Elnaz; Jamshidian Mojaver Majid; Naeemipour Mohsen; FARZIN Hamidreza

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2021 | Volume:15 | Issue:3 Page(s): 302-316

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Information Journal Paper

Title

The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity

Author(s)

Khajeh Elnaz | Jamshidian Mojaver Majid | Naeemipour Mohsen | FARZIN Hamidreza | Issue Writer Certificate

Keywords

Milk proteinsQ1

PepsinQ1

Antibacterial activityQ1

Staphylococcus aureusQ2

Pseudomonas aeruginosaQ2

Acinetobacter baumanniiQ1

Abstract

Background and Aim: Antimicrobial peptides have attracted significant attention in recent decades because of their properties, such as rapid bactericidal effects, having a wide spectrum of activity, and a rare development of drug resistance. The purpose of this study was to examine the Antibacterial activity of a peptide derived from the lactoferrin isolated from camel milk against Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. Materials and Methods: In the present study, by means of bioinformatics, an antibacterial peptide was potentially identified as candidates in lactoferrin of camel milk, and an appropriate peptide was selected based on defined criteria. The Pepsin-Camel-Lac1 peptide was synthesized. The methyl thiazolyl diphenyl-tetrazolium bromide assay was conducted to examine the toxicity of Pepsin-Camel-Lac1 against a cell line. Three pathogenic bacteria, namely S. aureus, P. aeruginosa, and A. baumannii were analyzed to assess the Antibacterial activity of Pepsin-Camel-Lac1 peptide. Results: The results showed that the newly-identified peptide had no toxicity against the cell line. The minimum inhibitory concentration values of Pepsin-Camel-Lac1 against S. aureus, P. aeruginosa, and A. baumannii were 31. 25 μ g/mL, 31. 25 μ g/mL, and 62. 5 μ g/mL, respectively. Conclusion: It seems that the growth of S. aureus, P. aeruginosa, and A. baumannii was not affected by Pepsin-Camel-Lac1 treatment in the bacterial culture medium.

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APA: Copy

Khajeh, Elnaz, Jamshidian Mojaver, Majid, Naeemipour, Mohsen, & FARZIN, Hamidreza. (2021). The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 15(3 ), 302-316. SID. https://sid.ir/paper/414456/en

Vancouver: Copy

Khajeh Elnaz, Jamshidian Mojaver Majid, Naeemipour Mohsen, FARZIN Hamidreza. The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2021;15(3 ):302-316. Available from: https://sid.ir/paper/414456/en

IEEE: Copy

Elnaz Khajeh, Majid Jamshidian Mojaver, Mohsen Naeemipour, and Hamidreza FARZIN, “The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 15, no. 3 , pp. 302–316, 2021, [Online]. Available: https://sid.ir/paper/414456/en

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