POTENTION OF ANALGENSIA EFFECT OF MORPHINOUS SUBSTANSES USING EPIDURAL CLONDINE.A STUDY ON 60 CASES

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KHOZAYMEH B.; SOHRABI FARIBA; YEGANEH M.A.

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Journal: Journal of Medical Council of Iran Year:2002 | Volume:19 | Issue:4 Page(s): 271-275

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Title

POTENTION OF ANALGENSIA EFFECT OF MORPHINOUS SUBSTANSES USING EPIDURAL CLONDINE.A STUDY ON 60 CASES

Author(s)

KHOZAYMEH B. | SOHRABI FARIBA | YEGANEH M.A. | Issue Writer Certificate

Keywords

CLONIDINEQ3

MORPHINEQ3

EPIDURALQ3

Abstract

As radioligand studies have defined, overlaping of "mu" and alpha two receptors distribution in the basal nuclei of the brain (locus ceruleus), and anterior horn of the spine, act synergistically. In fact, simultaneous administration of opiate and alpha two agonist have a sinificant synergetic effects in reducing pain. Therefore, we decided that using an alpha two agonist such as CLONIDINE, could prolong the anesthesia and painless period, without the need to increase doses of MORPHINE related compounds and as a result ,patients would not encounter side effects found with these drugs.This study was conducted on 60 patients with different sex and age, who had to be operated for orthopedic, surgical and urological problems under EPIDURAL anesthesia. They were randomly divided into two groups of A and B. Definite doses of anesthetic and MORPHINE related drugs were administered to both groups, but an additional dose of CLONIDINE was given to the group A only.According to the above table, with nearly equal conditions in both groups;(age, sex, HR and SBP),The effect of drugs was more prolonged in group A (338 min) who had recieved CLONIDINE, than group B without it which revealed a shorter period of drug effect (116 min). Knowing clodidines synergetic effect with morphin related drugs. Addition of CLONIDINE in the EPIDURAL space significantly prolongs the pain free and anesthetic effects. As a reasult makes the anesthetic and painless period much longer than the time it is not being used. Thus CLONIDINE is recommended when a longer anesthetic and painlese state is needed. in order to avoid the difficulties and complications associated with EPIDURAL catheter usage or side effects secondary to increase in MORPHINE dosage (respiratory depression etc),addition to an alpha two agonist such as CLONIDINE could be useful. of using EPIDURAL catheter and more important than that here is no need to increase the dose of morphin related drugs as a reasult keeps us on the safe side as far as the respiratory depression and other opiate side effects are concerned.

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APA: Copy

KHOZAYMEH, B., SOHRABI, FARIBA, & YEGANEH, M.A.. (2002). POTENTION OF ANALGENSIA EFFECT OF MORPHINOUS SUBSTANSES USING EPIDURAL CLONDINE.A STUDY ON 60 CASES. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 19(4), 271-275. SID. https://sid.ir/paper/41453/en

Vancouver: Copy

KHOZAYMEH B., SOHRABI FARIBA, YEGANEH M.A.. POTENTION OF ANALGENSIA EFFECT OF MORPHINOUS SUBSTANSES USING EPIDURAL CLONDINE.A STUDY ON 60 CASES. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2002;19(4):271-275. Available from: https://sid.ir/paper/41453/en

IEEE: Copy

B. KHOZAYMEH, FARIBA SOHRABI, and M.A. YEGANEH, “POTENTION OF ANALGENSIA EFFECT OF MORPHINOUS SUBSTANSES USING EPIDURAL CLONDINE.A STUDY ON 60 CASES,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 19, no. 4, pp. 271–275, 2002, [Online]. Available: https://sid.ir/paper/41453/en

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