Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus

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MOGHIMI HAMID; BORZOUEI SHIVA; ZAMANI ALIREZA; BEHZAD MAHDI

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Journal Paper

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Journal: Avicenna Journal of Clinical Medicine Year:2021 | Volume:27 | Issue:4 (SN 98) Page(s): 193-200

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Title

Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus

Author(s)

MOGHIMI HAMID | BORZOUEI SHIVA | ZAMANI ALIREZA | BEHZAD MAHDI | Issue Writer Certificate

Keywords

Diabetes Mellitus Type 2Q1

EmpagliflozinQ1

Interleukin 22Q1

T Helper 22 CellQ1

Abstract

Background and Objective: The increased response of T helper (Th) 22cells might be involved in thepathogenesis ofType 2 Diabetes Mellitus (T2DM). The present study aimed to investigate the transcription factor of Th22 cells (aryl hydrocarbon receptor [AHR]) and Interleukin 22 (IL-22) in CD4+ T cells as well as the impact of oral Empagliflozin treatment. The correlation between the aforementioned factors and clinical parameters was also determined among the patients. Materials and Methods: In this case-control study, 50 patients under the treatment of metformin and gliclazide were divided into two equal groups, including the patients receiving Empagliflozin (EMPA+) and not receiving Empagliflozin (EMPA, as the control group). The peripheral blood CD4+ T cells were isolated on the initiation day of the study and after 6 months of therapy, and the gene expression levels of AHR and IL-22 were evaluated by real-time polymerase chain reaction. In addition, the production of IL-22 after activation was measured using enzyme-linked immunosorbent assay. Results: The levels of fasting plasma glucose and hemoglobin A1c diminished in the EMPA+ group after Empagliflozin therapy, compared to those reported at the baseline (initiation day; P<0. 001 and P=0. 04). The gene expression level of IL-22 and production of IL-22 significantly reduced after 6 months of Empagliflozin therapy (P=0. 011 and P=0. 001). A significant positive correlation between IL-22 production and its gene expression with AHR as well as between fasting plasma glucose and hemoglobin A1c was observed in the EMPA+ patients after therapy (P˂ 0. 05). Conclusion: In addition to antidiabetic effects, Empagliflozin has anti-inflammatory impacts on the immune system, especially on Th22 cell-related factors.

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APA: Copy

MOGHIMI, HAMID, BORZOUEI, SHIVA, ZAMANI, ALIREZA, & BEHZAD, MAHDI. (2021). Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 27(4 (SN 98) ), 193-200. SID. https://sid.ir/paper/414617/en

Vancouver: Copy

MOGHIMI HAMID, BORZOUEI SHIVA, ZAMANI ALIREZA, BEHZAD MAHDI. Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2021;27(4 (SN 98) ):193-200. Available from: https://sid.ir/paper/414617/en

IEEE: Copy

HAMID MOGHIMI, SHIVA BORZOUEI, ALIREZA ZAMANI, and MAHDI BEHZAD, “Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 27, no. 4 (SN 98) , pp. 193–200, 2021, [Online]. Available: https://sid.ir/paper/414617/en

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