Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Yousefian Mahsa; ANGAJI SEYED ABDOLHAMID; SIASI ELHAM; RAHMANI SEYED ALI; Abbasalizadeh Khiaban Shamci

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Medicine Year:2021 | Volume:28 | Issue:2 (SN 100) Page(s): 118-125

Download Full-Text

Persian Verion

View:

306

Download:

Cites:

Information Journal Paper

Title

Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women

Author(s)

Keywords

Coagulation FactorsQ1

Plasminogen Activator Inhibitor 1Q2

Recurrent AbortionQ1

ThrombophiliaQ1

Abstract

Background and Objective: The mutation of F2 and PAI-1 genes can cause Thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1. Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplificationrefractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chisquared test (P˂ 0. 05). Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0. 222; 95%CI=0. 082-0. 599); nonetheless, no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0. 488-2. 049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0. 245; 95% CI=0. 066-0. 901). Conclusion: As evidenced by the obtained results, there was a protective association between rs6090 and RPL; nonetheless, there was no relationship between rs3136520 and RPL.

Cites

No record.

References

No record.

Cite

APA: Copy

Yousefian, Mahsa, ANGAJI, SEYED ABDOLHAMID, SIASI, ELHAM, RAHMANI, SEYED ALI, & Abbasalizadeh Khiaban, Shamci. (2021). Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 28(2 (SN 100)), 118-125. SID. https://sid.ir/paper/414700/en

Vancouver: Copy

Yousefian Mahsa, ANGAJI SEYED ABDOLHAMID, SIASI ELHAM, RAHMANI SEYED ALI, Abbasalizadeh Khiaban Shamci. Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2021;28(2 (SN 100)):118-125. Available from: https://sid.ir/paper/414700/en

IEEE: Copy

Mahsa Yousefian, SEYED ABDOLHAMID ANGAJI, ELHAM SIASI, SEYED ALI RAHMANI, and Shamci Abbasalizadeh Khiaban, “Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 28, no. 2 (SN 100), pp. 118–125, 2021, [Online]. Available: https://sid.ir/paper/414700/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops