The Modulatory Effects of Salbutamol in the Basolateral Nucleus of the Amygdala on Learning and Memory Impairments Induced by Foot-shock Stress in the Male Rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MEFTAHI GHOLAM HOSSEIN; BAHARI ZAHRA; AFARINESH MOHAMMAD REZA; Hatef Boshra

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2021 | Volume:26 | Issue:1 (111) Page(s): 53-71

Download Full-Text

Persian Verion

View:

209

Download:

Cites:

Information Journal Paper

Title

The Modulatory Effects of Salbutamol in the Basolateral Nucleus of the Amygdala on Learning and Memory Impairments Induced by Foot-shock Stress in the Male Rat

Author(s)

MEFTAHI GHOLAM HOSSEIN | BAHARI ZAHRA | AFARINESH MOHAMMAD REZA | Hatef Boshra | Issue Writer Certificate

Keywords

Barnes mazeQ1

β2-adrenergic receptorsQ1

Foot-shock StressQ1

Passive Avoidance TestQ1

SalbutamolQ3

Abstract

Background and Aim: Beta-adrenergic receptors in the basolateral nucleus of the amygdala (BLA) have been associated with stress, learning, and memory. In this study, we tested the effects of intra-BLA microinfusions of the β 2-adrenergic receptor agonist, Salbutamol, on spatial, passive avoidance memory and long-term potentiation (LTP) in the CA1 region of the hippocampus in response to stress. Materials and Methods: Forty male rats were randomly divided into five groups (n=8/per group): control, sham, stress, Salbutamol+control, and Salbutamol+stress. Bilateral cannulation was performed in the BLA, by using stereotaxic apparatus. Then, the rats were transferred to the communication box and Foot-shock Stress induction continued for four consecutive days. Five minutes before stress, Salbutamol (4 μ l/side) was injected bilaterally into the BLA. Barnes maze and shuttle box were examined for spatial and passive avoidance memory, respectively. The field potential recording was also used to investigate LTP in the CA1 neurons of the hippocampus. Results: The results of the Passive Avoidance Test showed that bilateral injection of Salbutamol in the BLA five minutes before stress increased step-through latency time significantly compared to the stress group. Barnes maze results showed that intra-BLA microinfusions of Salbutamol before stress, reduced the latency time, the number of errors, and the distance traveling to achieve the target hole compared to the stress group. Field potential recording revealed that Salbutamol injection before stress decreased the population spike amplitude significantly and caused fEPSP slope 60 minutes after high-frequency stimulation compared to the stress groups. Conclusion: It seems that the Salbutamol in the BLA can improve memory deficits induced by stress.

Cites

No record.

References

No record.

Cite

APA: Copy

MEFTAHI, GHOLAM HOSSEIN, BAHARI, ZAHRA, AFARINESH, MOHAMMAD REZA, & Hatef, Boshra. (2021). The Modulatory Effects of Salbutamol in the Basolateral Nucleus of the Amygdala on Learning and Memory Impairments Induced by Foot-shock Stress in the Male Rat. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 26(1 (111) ), 53-71. SID. https://sid.ir/paper/414846/en

Vancouver: Copy

MEFTAHI GHOLAM HOSSEIN, BAHARI ZAHRA, AFARINESH MOHAMMAD REZA, Hatef Boshra. The Modulatory Effects of Salbutamol in the Basolateral Nucleus of the Amygdala on Learning and Memory Impairments Induced by Foot-shock Stress in the Male Rat. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;26(1 (111) ):53-71. Available from: https://sid.ir/paper/414846/en

IEEE: Copy

GHOLAM HOSSEIN MEFTAHI, ZAHRA BAHARI, MOHAMMAD REZA AFARINESH, and Boshra Hatef, “The Modulatory Effects of Salbutamol in the Basolateral Nucleus of the Amygdala on Learning and Memory Impairments Induced by Foot-shock Stress in the Male Rat,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 (111) , pp. 53–71, 2021, [Online]. Available: https://sid.ir/paper/414846/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops