Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease

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BOZORGI HOOMAN; Darbanian Hamed

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Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:9 | Issue:1 Page(s): 1-5

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Title

Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease

Author(s)

BOZORGI HOOMAN | Darbanian Hamed | Issue Writer Certificate

Keywords

Alzheimer DiseaseQ2

Calcium Channel BlockersQ1

TherapeuticseQ1

Abstract

Introduction: Alzheimer’ s disease (AD) is the mos t common type of dementia in the elderly. Memory impairment usually occurs gradually and progressively. AD has not only been associated with decreased cerebral acetylcholine concentration, oxidative s tress, and beta-amyloid protein deposition, but more recent s tudies have shown that neurodegeneration induced by dis turbance of the intracellular calcium homeos tasis is also involved in the pathophysiology of the disease. It has been reported that Calcium Channel Blockers (CCBs) have beneficial effects in different models of memory impairment. Here, we review and discuss the effects of CCBs, especially N-types, as novel agents that have effects on memory deficits in animal models of AD. on contrary to the L-type calcium channels, which are presented in the other organs in addition to nerve cells, N-type calcium channels are commonly located on the neurons. The main advantage of N-type CCBs is their lower side effects than other CCBs. Conclusion: Targeting the N-type CCBs may contribute to the new s trategies for the treatment of AD.

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APA: Copy

BOZORGI, HOOMAN, & Darbanian, Hamed. (2021). Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 9(1 ), 1-5. SID. https://sid.ir/paper/414900/en

Vancouver: Copy

BOZORGI HOOMAN, Darbanian Hamed. Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2021;9(1 ):1-5. Available from: https://sid.ir/paper/414900/en

IEEE: Copy

HOOMAN BOZORGI, and Hamed Darbanian, “Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 9, no. 1 , pp. 1–5, 2021, [Online]. Available: https://sid.ir/paper/414900/en

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